ATI RN
Principles of Pharmacology Questions
Question 1 of 5
A 45-year-old woman recently diagnosed with lupus erythematosus started a treatment with a synthetic steroid. Which of the following is the most likely time lapse expected between receptor activation and therapeutic response?
Correct Answer: D
Rationale: The most likely time lapse expected between receptor activation and therapeutic response in this scenario would be one or two hours. This is because synthetic steroids usually act on intracellular receptors, which typically require some time to produce a therapeutic effect. The delay is due to the need for gene transcription and protein synthesis to occur in order to elicit the desired response. Therefore, the time frame of one to two hours aligns with the expected mechanism of action of synthetic steroids.
Question 2 of 5
Which of the following conditions most likely delayed the oral absorption of acetaminophen in the patient?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
Which of the following was most likely the oral bioavailability of the drug?
Correct Answer: D
Rationale: The oral bioavailability of a drug can be calculated using the formula F = AUC oral / AUC IV, where AUC is the area under the concentration-time curve. In this case, we are given the volume of distribution as 100 L and the theoretical plasma concentration at time 0 as 1 mg/L after oral administration of 200 mg. By calculating the AUC for both oral and IV routes, we can determine that the oral bioavailability is 1.0, which corresponds to option D.
Question 4 of 5
Which of the curves best depicts the log dose-response curve of that agonist when a fixed dose of a competitive α antagonist is given concomitantly?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
A 17-year-old boy drank increasing amounts of alcohol when attending parties. He noticed that lately he was able to better tolerate alcohol effects and asked his physician the reason for this. The physician said that pharmacodynamic tolerance had probably occurred. Which of the following actions most likely mediated this tolerance?
Correct Answer: B
Rationale: Pharmacodynamic tolerance refers to the body's ability to adapt to the effects of a drug, leading to decreased responsiveness. In this case, the boy's ability to better tolerate alcohol effects indicates a form of tolerance mediated by homeostatic adaptive changes that counteract the drug effect. This type of tolerance involves physiological adjustments to mitigate the impact of the drug, allowing the individual to withstand higher doses. Therefore, the correct answer is B.