ATI RN
Hematology Exam Questions Questions
Question 1 of 5
A 45-year-old man presents with deep vein thrombosis of the right femoral vein. Three months ago, he received a diagnosis of systemic lupus erythematosus (SLE). In addition to confirming SLE, laboratory testing also documented the presence of a lupus anticoagulant (LAC). There is no family history of venous thrombosis. Current medications include hydroxychloroquine. Laboratory testing shows normal results for a complete blood cell count and for tests of liver and kidney function. Special coagulation testing confirms the persistence of an LAC. What is the most reasonable duration of warfarin anticoagulation for this patient?
Correct Answer: D
Rationale: Persistent LAC and DVT in SLE meet antiphospholipid syndrome criteria, conferring high recurrence risk, necessitating long-term warfarin with periodic safety reassessment. Shorter durations (A, C, E) or 1 year (B) are inadequate.
Question 2 of 5
A 73-year-old woman presented to the emergency department with new-onset back pain, confusion, and constipation over the past week. Her past medical history is significant only for hypertension. On examination, she is slightly pale with slow cognition and point tenderness over the lumbar spine. Plain films of the lumbar spine show osteolytic lesions in L2, L3, and L5. Laboratory values are as follows: hemoglobin 9.3 g/dL, leukocyte count 4.6 × 10^9/L with a normal differential count, platelet count 230 × 10^9/L, creatinine 1.6 mg/dL, total calcium 13.1 mg/dL, albumin 3.6 g/dL, and total protein 9.1 g/dL. What is the most likely diagnosis?
Correct Answer: C
Rationale: Multiple myeloma presents with CRAB features (hypercalcemia, renal failure, anemia, bone lesions), matching this case (calcium 13.1 mg/dL, creatinine 1.6 mg/dL, hemoglobin 9.3 g/dL, osteolytic lesions). Other causes (A, B, D, E) don’t explain all findings.
Question 3 of 5
Appropriate long-term management of the disease described in Question 3 includes all of the following EXCEPT
Correct Answer: D
Rationale: Hemophilia A management includes A, B, C, and E (for mild cases), but splenectomy (D) is irrelevant as it doesn’t affect factor VIII levels.
Question 4 of 5
Matching: Hemolytic anemia - Oxidant stressors
Correct Answer: C
Rationale: Hereditary pyropoikilocytosis (C) is sensitive to oxidant stress, causing hemolysis, unlike sickle cell anemia (D).
Question 5 of 5
Matching: Anemia - Thalassemia
Correct Answer: A
Rationale: Thalassemia (A) is a classic microcytic anemia due to defective hemoglobin synthesis.