ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A 44-year-old woman with Crohn’s disease in the ileum and right colon is currently maintained on medical therapy including sulfasalazine. Symptoms are currently at baseline with minimal abdominal pain and diarrhea. The most likely reason for improved pain may relate to which of the following compounds/substances?
Correct Answer: D
Rationale: Sulfasalazine is metabolized in the gut to 5-aminosalicylate (mesalamine), which reduces inflammation in Crohn’s disease, alleviating pain and diarrhea.
Question 2 of 5
A 35-year-old woman with a history of world travel is found to have a hookworm infection. She has begun on therapy with mebendazole therapy orally and now returns home for follow-up. Which of the following statements regarding the pharmacodynamics of this agent is correct?
Correct Answer: B
Rationale: Mebendazole undergoes extensive hepatic first-pass metabolism, with poor systemic absorption, targeting intestinal parasites like hookworm effectively.
Question 3 of 5
Five patients with influenza A are being considered for treatment with either rimantadine or amantadine. Which of the following patients would be better suited to receive treatment with rimantadine?
Correct Answer: A
Rationale: Rimantadine has fewer CNS side effects (e.g., seizures) than amantadine, making it safer for a patient with epilepsy, as both drugs block the M2 ion channel of influenza A.
Question 4 of 5
A 32-year-old man with hepatitis B refractory to several treatments has begun on a course of lamivudine. The mechanism of action of this medication likely involves which of the following?
Correct Answer: A
Rationale: Lamivudine inhibits HBV DNA polymerase, a reverse transcriptase, preventing viral DNA replication in hepatitis B.
Question 5 of 5
A 25-year-old man with HIV disease presents to his primary care physician for management. His CD4 counts are dramatically lower than normal. He is being considered for therapy with protease inhibitors. Regarding the role of ritonavir in this patient, which of the following statements is true?
Correct Answer: C
Rationale: Ritonavir inhibits CYP3A4 (not CYP4A), boosting levels of other protease inhibitors in HAART, enhancing their efficacy, though it’s not typically used alone due to side effects.