A 44-year-old man with Type-2 diabetes presents to the ambulatory care clinic for follow-up. He was diagnosed with diabetes 6 months ago and was started on oral medication then. His blood sugar has been under good control with a hemoglobin \A_{1c of 6.7%. He has not had any hypoglycemic episodes. His only complaint is that despite daily exercise and eating healthier, he has gained 12lb in the last 6 months. What medication is most likely to cause his weight gain?

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Endocrine Pharmacology Quizlet Questions

Question 1 of 5

A 44-year-old man with Type-2 diabetes presents to the ambulatory care clinic for follow-up. He was diagnosed with diabetes 6 months ago and was started on oral medication then. His blood sugar has been under good control with a hemoglobin \A_{1c of 6.7%. He has not had any hypoglycemic episodes. His only complaint is that despite daily exercise and eating healthier, he has gained 12lb in the last 6 months. What medication is most likely to cause his weight gain?

Correct Answer: D

Rationale: Pioglitazone, a TZD, causes weight gain due to fluid retention and fat accumulation, despite good glucose control.

Question 2 of 5

A 55-year-old man presents to his primary care physician to follow up on his hyperlipidemia medication. Lab work suggests that his total cholesterol, LDL, triglycerides, and HDL are all within normal limits because of the lovastatin he began taking 2 months ago. He has not visited the office since being prescribed this medication. Which of the following lab tests should be obtained at the present office visit?

Correct Answer: C

Rationale: Lovastatin requires liver function tests (LFTs) after initiation to monitor for hepatotoxicity, a standard follow-up step.

Question 3 of 5

A patient presents with lethargy, tiredness, cold intolerance, dryness of skin and hair, hoarsness of voice and weight gain. He also has psychosis and his heart rate appears to be lower than normal. Which of the following is not associated with the presenting symptoms?

Correct Answer: D

Rationale: Hypothyroidism symptoms (lethargy, weight gain, etc.) are linked to Hashimoto's, cretinism, and iodine deficiency (low thyroid hormone). Increased iodine levels would cause hyperthyroidism, not these symptoms.

Question 4 of 5

A patient presents with tiredness, weakness, anorexia, apathy, abdominal pain, hyperpigmentation and postural hypertension. Upon infection he appears to be in cardiogenic shock and his blood volume is depleted. His sodium levels are low, potassium levels are high. Which of the following would also be elevated?

Correct Answer: D

Rationale: Addison's disease (adrenal insufficiency) causes hyperpigmentation, hyponatremia, hyperkalemia, and shock due to low cortisol; ACTH is elevated due to lack of negative feedback.

Question 5 of 5

A girl presents with delayed puberty, absent secondary sexual characteristics, and primary amenorrhea. She also appears to be hypertensive and hypokalemia. Which of the following enzymes is increased if there is virilization of a person?

Correct Answer: C

Rationale: 21-hydroxylase deficiency (CAH) causes hypertension, hypokalemia, and virilization (increased androgens) due to shunting from cortisol to androgen synthesis.

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