ATI RN
Endocrine Pharmacology Quiz Questions
Question 1 of 5
A 43-year-old man with dyslipidemia comes to the clinic for a routine checkup. He currently takes atorvastatin but is not achieving his target lipid profile. The physician prescribes colesevelam to help. Which of the following changes is expected as a result of this new therapy?
Correct Answer: C
Rationale: Colesevelam, a bile acid sequestrant, can cause hyperglycemia by reducing insulin sensitivity, though it lowers LDL.
Question 2 of 5
An 18-year-old female with diabetes presents to the clinic for her annual visit. Over the past year, she has experienced daily nausea and occasional vomiting. She has learned that eating small amounts of food at a time helps to decrease the frequency of vomiting. She is diagnosed with diabetic gastroparesis and started on metoclopramide. What is a side effect of metoclopramide?
Correct Answer: D
Rationale: Metoclopramide, a prokinetic, can cause tardive dyskinesia, a serious movement disorder, with prolonged use.
Question 3 of 5
A 37-year-old man is found to have hypercholesterolemia during a routine checkup. The physician prescribes lovastatin and counsels the patient to make healthy dietary and lifestyle changes to keep his cholesterol under control. Two months later, he returns for a follow-up visit, and the physician discovers his LDL level remains virtually unchanged. He insists that he is taking the medication exactly as prescribed. The physician knows lovastatin is metabolized by the cytochrome P450 3A4. What else may he be using that would explain his condition?
Correct Answer: D
Rationale: St. John's wort induces CYP3A4, increasing lovastatin metabolism and reducing its efficacy, explaining unchanged LDL.
Question 4 of 5
A 27-year-old woman presents to clinic with infertility over the past 2 years. Her husband had a normal sperm analysis. She has also had weight gain and increased facial hair. Her labs show an increase in both her LH and FSH, with a ratio of LH:FSH of 2:1. What is the most appropriate medication to help her with her infertility?
Correct Answer: A
Rationale: Clomiphene induces ovulation in PCOS (suggested by LH:FSH >2:1, hirsutism), addressing her infertility.
Question 5 of 5
A 76-year-old man presents to the clinic for follow-up of his benign prostatic hyperplasia. He has been doing well with his symptoms since starting finasteride. He no longer has as much difficulty starting his stream and feels that he empties his bladder completely. What is the mechanism of action of finasteride?
Correct Answer: A
Rationale: Finasteride inhibits 5alpha-reductase, reducing DHT levels, shrinking prostate size, and relieving BPH symptoms.