A 42-year-old woman with a history of systemic lupus erythematosus (SLE) presents with fatigue. She has been receiving anti-tumor necrosis factor therapy and has been managing the SLE well. However, she has recently experienced worsening fatigue. Her vital signs are normal. Her face and conjunctivae are jaundiced, and she has a fading butterfly rash on her face. The spleen is palpable on deep inspiration. Diagnostic testing results are shown in Table 9.Q6, and the peripheral blood film is shown in Figure 9.Q6. Which of the following is the best interpretation of these data?

A 42-year-old woman with a history of systemic lupus erythematosus (SLE) presents with fatigue. She has been receiving anti-tumor necrosis factor therapy and has been managing the SLE well. However, she has recently experienced worsening fatigue. Her vital signs are normal. Her face and conjunctivae are jaundiced, and she has a fading butterfly rash on her face. The spleen is palpable on deep inspiration. Diagnostic testing results are shown in Table 9.Q6, and the peripheral blood film is shown in Figure 9.Q6. Which of the following is the best interpretation of these data?

An 80-year-old man is admitted to the hospital after falling on an icy sidewalk and fracturing his hip. He undergoes open reduction and internal fixation of the fracture. At surgery, there does not appear to be any bone disease at the fracture site. The patient was previously asymptomatic. Physical examination findings are otherwise unremarkable. Serum protein electrophoresis and immunofixation show an IgM κ monoclonal protein (0.3 g/dL). The complete blood cell count and serum creatinine levels are normal. Skeletal survey shows no additional bone defects. Which of the following statements is true for this patient?

A 5-year-old white female has multiple bruises on her lower extremities and oral mucosal bleeding of 3 days' duration. Two weeks before these signs, she had a mild respiratory tract infection. Physical examination reveals multiple ecchymoses and petechiae; no lymphadenopathy or hepatosplenomegaly is noted. The next diagnostic step is

A 5-day-old full-term male presents with intense cyanosis, tachypnea, and tachycardia. Physical examination reveals cyanosis of the skin and mucous membranes; the lungs, heart, pulses, and general examination show no abnormalities. Arterial blood gas determination reveals a PaOâ‚‚ of 95 while the patient is breathing room air and an oxygen saturation of 40%. The most likely diagnosis is

Matching: Hemolytic anemia - Microcytosis