ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A 42-year-old man with a history of recurrent mycoplasma pulmonary infections presents with similar complaints. Sputum culture reveals that the organism present demonstrates resistance to erythromycin and the macrolide antibiotic class. What is the most likely explanation for this finding?
Correct Answer: C
Rationale: Mycoplasma resistance to erythromycin is often due to plasmid-associated erythromycin esterase, which hydrolyzes the drug, rendering it inactive.
Question 2 of 5
A 39-year-old man with HIV disease and active tuberculosis is hospitalized for therapy. He currently takes a protease inhibitor. He complains of cough, dyspnea, and chest pressure. Which of the following is the best treatment adjunct for this patient?
Correct Answer: B
Rationale: Rifabutin is preferred over rifampin in HIV patients on protease inhibitors due to fewer drug interactions with cytochrome P450, effectively treating TB while maintaining HIV therapy.
Question 3 of 5
A 35-year-old woman with a history of world travel is found to have a hookworm infection. She has begun on therapy with mebendazole therapy orally and now returns home for follow-up. Which of the following statements regarding the pharmacodynamics of this agent is correct?
Correct Answer: B
Rationale: Mebendazole undergoes extensive hepatic first-pass metabolism, with poor systemic absorption, targeting intestinal parasites like hookworm effectively.
Question 4 of 5
Five patients with influenza A are being considered for treatment with either rimantadine or amantadine. Which of the following patients would be better suited to receive treatment with rimantadine?
Correct Answer: A
Rationale: Rimantadine has fewer CNS side effects (e.g., seizures) than amantadine, making it safer for a patient with epilepsy, as both drugs block the M2 ion channel of influenza A.
Question 5 of 5
A 32-year-old man with hepatitis B refractory to several treatments has begun on a course of lamivudine. The mechanism of action of this medication likely involves which of the following?
Correct Answer: A
Rationale: Lamivudine inhibits HBV DNA polymerase, a reverse transcriptase, preventing viral DNA replication in hepatitis B.