A 4 year old child had Mantoux test. 60 hours after tuberculin introduction a focal skin hardening and redness 15 mm in diameter appeared. It was regarded as positive test. What type of hypersensitivity reaction is this test based upon?

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Microbiology Chapter 11 Test Bank Questions

Question 1 of 9

A 4 year old child had Mantoux test. 60 hours after tuberculin introduction a focal skin hardening and redness 15 mm in diameter appeared. It was regarded as positive test. What type of hypersensitivity reaction is this test based upon?

Correct Answer: A

Rationale: The correct answer is A: Delayed-type hypersensitivity. The Mantoux test is a type IV hypersensitivity reaction, which is also known as delayed-type hypersensitivity. This reaction typically occurs 48-72 hours after exposure to an antigen, such as tuberculin in this case. The focal skin hardening and redness that appeared 60 hours after tuberculin introduction align with the timeline and characteristics of a delayed-type hypersensitivity reaction. Summary: - Choice A (Delayed-type hypersensitivity): Correct, as explained above. - Choice B (Immune complex-mediated hypersensitivity): Incorrect, as this reaction involves immune complexes and typically presents with tissue damage and inflammation. - Choice C (Complement-mediated cytotoxic hypersensitivity): Incorrect, as this reaction involves the activation of complement proteins leading to cell lysis. - Choice D (Immediate hypersensitivity): Incorrect, as this reaction, such as in allergies, occurs within minutes to hours of exposure to an antigen and involves IgE-mediated mast

Question 2 of 9

The typhoid fever is produced mainly by:

Correct Answer: D

Rationale: The correct answer is D: Salmonella typhi. Typhoid fever is caused by the bacterium Salmonella typhi. This bacterium is responsible for causing the systemic infection that leads to symptoms such as high fever, abdominal pain, and diarrhea. Yersinia pestis (choice A) causes plague, Shigella dysenteriae (choice B) causes dysentery, and Escherichia coli (choice C) can cause various gastrointestinal infections, but not typhoid fever. Salmonella typhi specifically targets the intestines and is transmitted through contaminated food or water. Therefore, choice D is the correct answer for the cause of typhoid fever.

Question 3 of 9

Many peptic ulcers are due to:

Correct Answer: B

Rationale: The correct answer is B, Helicobacter pylori. This bacterium is the main cause of peptic ulcers by damaging the protective lining of the stomach and duodenum. It secretes enzymes that weaken the mucosal barrier, allowing stomach acid to cause damage. Salmonella typhi (A) causes typhoid fever, not peptic ulcers. Shigella boydii (C) causes dysentery, not peptic ulcers. Salmonella enterica (D) causes food poisoning, not peptic ulcers. Therefore, the correct answer is B based on its direct association with peptic ulcer formation.

Question 4 of 9

Dwellers of a village noticed mass mortality of rats in some farms. It was suspected that the animals might have died from plague. What postmortal analyses should be conduced in order to establish the causative agent of the infection as soon as possible?

Correct Answer: B

Rationale: The correct answer is B: Agglutination reaction. This test is commonly used to detect specific antibodies or antigens. In this case, it can be used to detect plague antigens in the rat tissues or antibodies in the villagers. This test is rapid, sensitive, and can help establish the presence of the causative agent quickly. A: Ring precipitation reaction is not typically used for diagnosing plague and is more commonly used in other types of infections. C: Passive agglutination reaction is not specific for plague and is more commonly used for detecting specific antibodies in diseases like syphilis. D: Neutralization reaction is not typically used for diagnosing plague and is more commonly used to determine the presence of neutralizing antibodies in viral infections.

Question 5 of 9

A woman hospitalized in the surgical department complains of pain in her lower abdomen and in the small of her back, frequent and painful urination. Urine culture test revealed gram-negative oxidase- positive bacilli that formed green mucoid colonies with specific smell. What causative agent can be suspected?

Correct Answer: D

Rationale: The correct answer is D: Proteus mirabilis. The patient's symptoms of lower abdominal pain, back pain, frequent/painful urination, and the presence of gram-negative oxidase-positive bacilli forming green mucoid colonies with a specific smell suggest a urinary tract infection caused by Proteus mirabilis. This bacterium is known for causing UTIs and is characterized by its swarming motility and distinctive odor. A: Pseudomonas aeruginosa is commonly associated with hospital-acquired infections but does not typically cause UTIs with the specific characteristics described. B: Mycoplasma pneumonia is a bacterium that causes respiratory infections, not UTIs. C: Str.pyogenes (Streptococcus pyogenes) is a common cause of strep throat and skin infections, not UTIs. D: Helicobacter pylori is associated with gastritis and peptic ulcers, not UTIs.

Question 6 of 9

What are the two main targets currently used in anti-HIV therapy?

Correct Answer: B

Rationale: The correct answer is B: Reverse transcriptase and protease. Reverse transcriptase converts viral RNA into DNA, a crucial step in viral replication. Protease is responsible for cleaving viral polyproteins into functional proteins. Targeting both enzymes disrupts viral replication. Choice A is incorrect as integrase is not a main target in current therapy. Choice C is incorrect because protease is targeted along with reverse transcriptase, not integrase. Choice D is incorrect as targeting viral glycoproteins is not a main strategy in anti-HIV therapy.

Question 7 of 9

Which bacteria is known for causing the disease tetanus?

Correct Answer: A

Rationale: Step-by-step rationale for why A is correct: 1. Clostridium tetani is known to produce tetanus toxin. 2. The tetanus toxin causes muscle rigidity and spasms characteristic of tetanus. 3. Clostridium perfringens is associated with gas gangrene, not tetanus. 4. Neisseria gonorrhoeae causes gonorrhea, not tetanus. 5. Bacillus anthracis causes anthrax, not tetanus. In summary, Clostridium tetani is the correct answer as it is specifically associated with causing tetanus, while the other choices are associated with different diseases.

Question 8 of 9

Axial filaments consist of

Correct Answer: A

Rationale: Axial filaments, also known as endoflagella, are composed of proteins. These proteins form a helical structure that enables certain bacteria, such as spirochetes, to move in a corkscrew-like motion. Proteins are the main structural component of axial filaments due to their flexibility and ability to generate movement. Choice B, polyphosphates, are not typically associated with axial filaments, as they are more involved in energy storage and transfer. Choice C, volutin granules, are storage inclusions of inorganic polyphosphate and are not part of axial filaments. Choice D, carbohydrates, are not the primary component of axial filaments which are protein-based structures responsible for bacterial motility.

Question 9 of 9

During bacteriological examination of sputum of a child with choking cough and fever there were revealed glossy smooth colonies growing on casein-charcoal agar and reminding of mercury drops. Microscopic examination revealed short Gram-negative bacteria. What microorganism was secured from the sputum?

Correct Answer: A

Rationale: The correct answer is A: Bordetella pertussis. Glossy smooth colonies growing on casein-charcoal agar resembling mercury drops indicate Bordetella pertussis, the causative agent of whooping cough. The presence of short Gram-negative bacteria further supports this identification. Option B, Haemophilus influenzae, typically grows as small, round, translucent colonies on chocolate agar. Option C, Corynebacterium diphtheriae, forms gray colonies on tellurite agar. Option D, Klebsiella pneumoniae, appears as mucoid colonies on MacConkey agar.

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