A 4 year old child had Mantoux test. 60 hours after tuberculin introduction a focal skin hardening and redness 15 mm in diameter appeared. It was regarded as positive test. What type of hypersensitivity reaction is this test based upon?

Correct Answer: A

Rationale: The correct answer is A: Delayed-type hypersensitivity. The Mantoux test is a type IV hypersensitivity reaction, which is also known as delayed-type hypersensitivity. This reaction typically occurs 48-72 hours after exposure to an antigen, such as tuberculin in this case. The focal skin hardening and redness that appeared 60 hours after tuberculin introduction align with the timeline and characteristics of a delayed-type hypersensitivity reaction. Summary: - Choice A (Delayed-type hypersensitivity): Correct, as explained above. - Choice B (Immune complex-mediated hypersensitivity): Incorrect, as this reaction involves immune complexes and typically presents with tissue damage and inflammation. - Choice C (Complement-mediated cytotoxic hypersensitivity): Incorrect, as this reaction involves the activation of complement proteins leading to cell lysis. - Choice D (Immediate hypersensitivity): Incorrect, as this reaction, such as in allergies, occurs within minutes to hours of exposure to an antigen and involves IgE-mediated mast

Correct Answer: A

Rationale: The correct answer is A: IgG. Anti-tetanus gamma globulin is produced by hyperimmunization, leading to a high concentration of specific antibodies, predominantly IgG. IgG is the most abundant immunoglobulin in the blood and provides long-term immunity against tetanus. IgA is mainly found in mucosal areas, not in gamma globulin preparations. IgM is the first antibody produced in response to an infection and is not the prevailing class in this preparation. IgE is associated with allergic reactions and parasitic infections, not with anti-tetanus immunity.

Correct Answer: B

Rationale: The correct answer is B: Agglutination reaction. This test is commonly used to detect specific antibodies or antigens. In this case, it can be used to detect plague antigens in the rat tissues or antibodies in the villagers. This test is rapid, sensitive, and can help establish the presence of the causative agent quickly. A: Ring precipitation reaction is not typically used for diagnosing plague and is more commonly used in other types of infections. C: Passive agglutination reaction is not specific for plague and is more commonly used for detecting specific antibodies in diseases like syphilis. D: Neutralization reaction is not typically used for diagnosing plague and is more commonly used to determine the presence of neutralizing antibodies in viral infections.

Correct Answer: C

Rationale: Rationale: 1. Helicobacter pylori is known for producing urease enzyme to neutralize stomach acid. 2. Urease enzyme converts urea into ammonia, buffering the acidic pH. 3. This adaptation allows H. pylori to survive in the acidic environment of the stomach. 4. Salmonella typhi, Escherichia coli, and Shigella flexneri do not produce urease. 5. Therefore, C is the correct answer based on the unique urease-producing capability of H. pylori.

Correct Answer: A

Rationale: The correct answer is A: Entamoeba histolytica. This is because it is the only choice that matches the description of cysts with four nuclei, characteristic of Entamoeba histolytica. Entamoeba histolytica is a protozoan parasite that causes amoebiasis, leading to symptoms like persistent diarrhea. The other choices can be eliminated for the following reasons: B: Balantidium coli - It is a ciliated protozoan that causes dysentery in humans but does not produce cysts with four nuclei. C: Giardia lamblia - It is a flagellated protozoan that causes giardiasis, but it forms cysts with only two nuclei. D: Trichomonas hominis - It is a flagellated protozoan found in the human intestine, but it does not produce cysts with four nuclei. Therefore, based on the description of cysts with four nuclei in the stool sample,

Correct Answer: A

Rationale: The correct answer is A: Contaminated. The air is never completely free of microorganisms, so it is considered contaminated. Microorganisms are ubiquitous in the environment. Permissible limits (B) imply a specific standard, which is not relevant to the general microbiological characteristic of air. Almost pure (C) and pure (D) are not accurate as air always contains some level of microorganisms.

Correct Answer: A

Rationale: The correct answer is A: incidence. Incidence refers to the number of new cases of a disease occurring within a specific time period in relation to the healthy population. It helps in understanding the risk of developing the disease. Prevalence (B) is the total number of existing cases at a given point in time. Virulence (C) is the severity of the disease once contracted. Mortality (D) refers to the number of deaths due to the disease, not the new cases. Therefore, the correct term for new cases is incidence.

Correct Answer: A

Rationale: The correct answer is A: Β-lactamase. In ELISA, enzymes like alkaline phosphatase, horseradish peroxidase, and Β-galactosidase are commonly used as labels to detect the presence of specific molecules. Β-lactamase is not typically used in ELISA as it is an enzyme used to hydrolyze β-lactam antibiotics. Therefore, it does not serve the purpose of detecting specific molecules in ELISA. Alkaline phosphatase, horseradish peroxidase, and Β-galactosidase are preferred enzymes in ELISA due to their ability to produce a detectable signal when bound to specific molecules.

Correct Answer: B

Rationale: The correct answer is B: Staphylococcus aureus. This bacterium is known as a common cause of hospital-acquired infections due to its ability to colonize the skin and mucous membranes of healthcare workers and patients. Staphylococcus aureus can cause various infections, including surgical site infections and bloodstream infections, in healthcare settings. Rationale: 1. Clostridium botulinum is known for causing foodborne botulism, not hospital-acquired infections. 2. Treponema pallidum causes syphilis, which is primarily transmitted through sexual contact, not hospital settings. 3. Mycobacterium leprae causes leprosy, which is not commonly associated with hospital-acquired infections. In summary, Staphylococcus aureus is the correct answer as it is a common cause of hospital-acquired infections due to its prevalence in healthcare environments, unlike the other choices which are not typically associated with hospital-acquired infections.