Correct Answer: A

Rationale: Rheumatoid arthritis is a systemic autoimmune disease that primarily affects the joints. It commonly presents with pain, swelling, and stiffness in multiple small joints such as those in the hands, wrists, and feet. It is more prevalent in females in their 30s to 50s. Rheumatoid arthritis is characterized by chronic inflammation of the synovial membrane, leading to joint damage and deformities over time. Laboratory tests showing elevated inflammatory markers, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), along with positive rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies, can help in confirming the diagnosis of rheumatoid arthritis.

Correct Answer: C

Rationale: The obturator sign is a physical examination maneuver used to assess for irritation of the obturator muscle due to an inflamed appendix that is in close proximity. This pain is typically felt in the right lower quadrant or hypogastric region. The sign is elicited by passively flexing the hip and knee of the patient, then internally rotating the hip. An alternative method is to position the patient on her left side and ask her to raise her right thigh against resistance while the examiner provides counterpressure. Pain experienced by the patient with these maneuvers is consistent with obturator sign, indicating possible appendicitis. Hence, option C is the correct answer.

Correct Answer: B

Rationale: The description of an oval, brown, slightly elevated lesion with a flat surface and rough, wartlike texture on palpation is characteristic of a seborrheic keratosis. Seborrheic keratoses are common benign skin growths that typically occur in older adults. They can vary in color, ranging from tan to dark brown, and often have a waxy or stuck-on appearance. The lesion described does not fit the typical characteristics of actinic keratosis, basal cell carcinoma, or squamous cell carcinoma.

Correct Answer: A

Rationale: The patient in the case presented has multiple moist papules on the penile shaft and corona, which are classic features of condylomata acuminata, also known as genital warts. Condylomata acuminata are caused by the human papillomavirus (HPV) and are typically painless, unlike other conditions such as genital herpes or syphilitic chancre which may be associated with pain or tender sores. Given the patient's history of multiple sexual partners and lack of condom use with his current girlfriend, there is a higher likelihood of exposure to HPV. Condylomata acuminata can be treated with various options including topical agents, cryotherapy, or surgical removal, and it is important to address the potential risk of HPV transmission to sexual partners.

Correct Answer: A

Rationale: The clinical presentation described in the scenario is consistent with benign prostatic hyperplasia (BPH). BPH is a non-cancerous enlargement of the prostate gland, typically seen in older males. The findings of a smooth, enlarged prostate on digital rectal examination without discrete masses, along with the absence of other alarming signs such as blood in the urine or on examination, make BPH the most likely diagnosis in this case.