ATI RN
Pharmacology Across the Lifespan Quizlet Questions
Question 1 of 5
A 34-year-old woman with long-standing hypertension is taking an ACE inhibitor. She is now newly married. Which of the following potential adverse effects is most applicable to her at this time?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
A 32-year-old man who traveled to Brazil 1 week ago presents to the emergency department with swelling of his right eye. He has decreased vision in his right eye because of the swelling. His left eye is unaffected. A peripheral blood smear shows the presence of a parasite. The patient does remember being warned of reduviid bugs and that their bites are painless. What is the most appropriate treatment for this patient?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A 62-year-old man is being treated with cisplatin for small cell carcinoma of the lungs. The efficacy of cisplatin depends on interaction with which of the following?
Correct Answer: A
Rationale: Cisplatin is a platinum-based chemotherapeutic agent that exerts its cytotoxic effect by binding to DNA (A), forming intrastrand and interstrand cross-links. This disrupts DNA replication and transcription, leading to apoptosis of rapidly dividing cancer cells like small cell lung carcinomDNA polymerase is indirectly affected, not directly targeteGrowth factor receptors are targeted by tyrosine kinase inhibitors, reverse transcriptase by antiretrovirals, and ribosomes (E) by antibiotics like tetracyclines—none apply to cisplatin’s mechanism.
Question 4 of 5
A 60-year-old woman comes to the physician because she recently was diagnosed with non-small cell lung carcinoma and she wants to discuss possible treatment options. She tells the physician that she is concerned about the possible adverse effects of chemotherapy. The physician says that serious toxicity caused by antineoplastic drugs is seen in the bone marrow. Which of the following best explains this finding?
Correct Answer: A
Rationale: Bone marrow toxicity (e.g., myelosuppression) from chemotherapy occurs because marrow cells divide rapidly (A), making them highly susceptible to drugs targeting cell division (e.g., alkylating agents, antimetabolites). Specific targets apply to some drugs (e.g., imatinib), not most. ‘Used to prevent’ is unclear, nucleated cells aren’t the sole target (red cells lack nuclei), vascularity (E) aids delivery but isn’t the reason, and lipid solubility (F) varies by drug.
Question 5 of 5
A patient with type 2 diabetes mellitus asks the nurse how metformin decreases blood sugar. What is the best response by the nurse?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.