A 34-year-old man is a chronic alcoholic and is in and out of a rehabilitation center on a monthly basis. His physician administers a blocker of aldehyde dehydrogenase. Which of the following effects is most likely to be exhibited by this patient following administration?

Correct Answer: D

Rationale: Disulfiram, an aldehyde dehydrogenase blocker, is used in alcoholism to deter drinking. When alcohol is consumed, acetaldehyde accumulates, causing nausea . Bradycardia isn't typical; tachycardia may occur with acetaldehyde buildup. Elation and euphoria contradict the aversive intent. Urticaria (E) is possible but less common. Nausea, with flushing and vomiting, creates an unpleasant reaction, reinforcing abstinence. This aligns with disulfiram's mechanism, leveraging acetaldehyde toxicity to modify behavior, distinguishing it from other effects.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Bromocriptine, a dopamine D2 agonist used in Parkinson's, has ergot alkaloid properties, which can cause vasospasm by stimulating vascular smooth muscle receptors, occasionally leading to Raynaud's-like symptoms or digital ischemia. Amantadine, an NMDA antagonist, enhances dopamine release but lacks vasoconstrictive effects. Carbidopa inhibits dopa decarboxylase, aiding levodopa delivery without vascular impact. Entacapone, a COMT inhibitor, extends levodopa's duration but doesn't affect vessels. Ropinirole, a non-ergot agonist, avoids vasospasm. Bromocriptine's ergot-derived vasoconstriction, though rare, distinguishes it among antiparkinsonian drugs, requiring caution in patients with vascular risks.

Correct Answer: B

Rationale: Aspirin's use for pain involves anti-inflammatory and analgesic properties, but it risks GI irritation. Enteric-coated capsules minimize this by dissolving in the intestine, not the stomach, reducing bleeding risk—an accurate statement. High doses are true for anticoagulation, not pain relief, where lower doses suffice. Herbs like garlic and ginger increase bleeding risk, not inflammation relief, making it dangerous advice. Low doses (choice D, 325 mg) primarily prevent clotting, not significantly reduce inflammation, which requires higher doses. Choice B correctly reflects a practical measure to enhance aspirin's safety profile for pain management.

Correct Answer: D

Rationale: Conventional antipsychotics (e.g., haloperidol) cause anticholinergic effects like urinary retention , a potential emergency risking bladder damage, requiring immediate reporting. Dystonia is extrapyramidal, not anticholinergic. Headache and hypertension aren't typical anticholinergic signs. D prioritizes urgent intervention, making it the correct choice.