A 30 year old patient consulted a doctor about having diarrhea and stomach aches for 5 days, temperature rise up to 37,50C with chills. The day before the patient was in a forest and drank some water from an open pond. He was diagnosed with amebic dysentery that was bacteriologically confirmed. Name the medication for treatment of this disease:

Correct Answer: A

Rationale: The correct answer is A: Metronidazole. Amebic dysentery is caused by the parasite Entamoeba histolytica, not a bacterium, hence antibiotics like Chloramphenicol or Phthalazole are ineffective. Metronidazole is the drug of choice for treating amebic dysentery due to its efficacy against anaerobic organisms like Entamoeba histolytica. Furasolidone is used for treating bacterial infections, not parasitic ones like amebiasis. The patient's symptoms of diarrhea, stomach aches, and a recent history of drinking water from a potentially contaminated source in the forest are indicative of a parasitic infection, supporting the choice of Metronidazole for treatment.

Correct Answer: A

Rationale: The correct answer is A: Neisser. Bacterial capsules can be stained using the Neisser staining method because it specifically targets the capsule, making it visible under a microscope. Neisser staining involves using a combination of acidic and basic dyes to highlight the capsule structure. This method helps differentiate the capsule from the bacterial cell, aiding in the identification and study of capsules. Choices B, C, and D are incorrect because Cleat and Müller staining methods are not commonly used for staining bacterial capsules, and "None of the above" is incorrect as Neisser staining is a valid method for capsule staining.

Correct Answer: B

Rationale: The correct answer is B: Mycobacterium tuberculosis. This bacterium is specifically associated with tuberculosis, a contagious disease that primarily affects the lungs. Mycobacterium leprae (choice A) is associated with leprosy, not tuberculosis. Neisseria gonorrhoeae (choice C) causes gonorrhea, a sexually transmitted infection. Streptococcus pneumoniae (choice D) is known for causing pneumonia, not tuberculosis. Therefore, based on the association with the disease tuberculosis, the correct answer is Mycobacterium tuberculosis.

Correct Answer: D

Rationale: The correct answer is D: Shigella dysenteriae I. This bacterium is known to produce Shiga toxin, which is responsible for the most severe bacillary infections. The toxin can cause bloody diarrhea and potentially life-threatening complications like hemolytic uremic syndrome. Shigella boydii, flexneri, and sonnei, while also causing bacillary dysentery, do not produce the same level of severity as Shigella dysenteriae I due to the absence of Shiga toxin.

Correct Answer: B

Rationale: The correct answer is B: peak effect. When drug receptors are maximally activated, it means the drug has reached its highest effectiveness, resulting in the peak effect. This occurs when the drug concentration is at its highest level in the body, leading to the maximum response. Threshold level (A) refers to the minimum amount of drug needed to produce a response. Cessation effect (C) is when the drug's effect wears off. Latency time (D) is the time it takes for the drug to start producing an effect. So, the peak effect best describes the scenario where drug receptors are maximally activated.

Correct Answer: A

Rationale: The correct answer is A: Streptococcus pneumoniae. This bacterium is the most likely causative agent because it is a Gram-positive cocci in pairs with a capsule, which matches the description provided. S. pneumoniae is a common cause of bacterial pharyngitis and can present with sore throat. Summary of other choices: B: Staphylococcus aureus is a Gram-positive cocci in clusters, not pairs, and is not typically associated with sore throat. C: Neisseria meningitidis is a Gram-negative diplococcus and more commonly causes meningitis or septicemia, not sore throat. D: Klebsiella pneumoniae is a Gram-negative rod bacterium, not a Gram-positive cocci, and is not a common cause of sore throat.

Correct Answer: B

Rationale: The correct answer is B: Aminoglycosides. Aminoglycosides are antibiotics that act by binding to the 30S ribosomal subunit, disrupting protein synthesis in bacteria. This interaction affects the ribosomes directly, leading to inhibition of bacterial protein production. Penicillins (A) work by inhibiting cell wall synthesis, Sulfonamides (C) target folic acid synthesis, and Quinolones (D) inhibit DNA gyrase. These mechanisms do not directly affect the ribosomes, making them incorrect choices in this context.

Correct Answer: B

Rationale: The correct answer is B: Cholera. Cholera is caused by Gram-negative curved rod-like bacteria called Vibrio cholerae, commonly found in contaminated water or food. The characteristic symptom of cholera is profuse watery diarrhea, which matches the patient's presentation. Typhoid fever (A) is caused by Salmonella typhi, which is not a curved rod-like bacteria. Diphtheria (C) is caused by Corynebacterium diphtheriae, a Gram-positive bacterium, and does not typically cause diarrhea. Intestinal form of plague (D) is caused by Yersinia pestis, which is not a curved rod-like bacteria and does not typically present with diarrhea.

Correct Answer: C

Rationale: The correct answer is C, Meat-peptone agar, as it provides a simple nutritive media for bacterial growth. This agar contains meat extract and peptone, which are good sources of nutrients for bacterial growth. Glucose broth (A) is a liquid medium with glucose but lacks other essential nutrients. Ascites (serum) agar (B) is a selective medium used for detecting pathogens in clinical samples. Blood agar (D) is a differential medium used to distinguish different types of bacteria based on hemolytic reactions. Meat-peptone agar is the simplest and most general-purpose medium among the options provided.