ATI RN
Pharmacology Across the Lifespan ATI Questions
Question 1 of 5
A 30-year-old man presented to the clinic with a 2-month history of right-side head pain recurring on a weekly basis. His headaches were usually preceded by unformed flashes of light, bilaterally, and were associated with nausea, vomiting, and photophobia. The headaches were not relieved by aspirin or ibuprofen and usually lasted all day unless he was able to sleep. A drug acting on which of the following receptors would be most appropriate to stop the migraine attack in this patient?
Correct Answer: D
Rationale: The correct answer is D: 5-HT1B/1D serotonergic receptors. Migraine headaches are believed to be caused by neurovascular dysfunction involving serotonin pathways. Activating 5-HT1B/1D receptors can help constrict blood vessels and inhibit the release of pro-inflammatory neuropeptides, thus relieving migraine symptoms. Beta-2 adrenergic (choice A) receptors are not typically involved in migraine pathophysiology. GABAergic (choice B) drugs may be used for other types of headaches but are not specific for migraines. M1 cholinergic (choice C) drugs are not commonly used for migraine treatment as they do not target the serotonin pathways involved in migraines.
Question 2 of 5
A48-year-old woman was admitted to the emergency department because of fever (103.1°F, 39.5°C), flushing, sweating, tremors, and altered consciousness. Medical history indicated that she had been suffering from depression for 8 years, currently treated with paroxetine, and for insomnia, currently treated with zolpidem. The patient also reported that 24 hours earlier, she had self-administered three tablets of a drug given to her by a friend to treat a severe headache. Further exams confirmed the preliminary diagnosis, and an appropriate treatment was started. Which of the following drugs most likely triggered the patient's disorder?
Correct Answer: B
Rationale: Step 1: Recognize the symptoms described in the scenario: fever, flushing, sweating, tremors, altered consciousness. These symptoms are indicative of serotonin syndrome. Step 2: Identify the patient's medications that can contribute to serotonin syndrome: paroxetine (an SSRI) and zolpidem (a CNS depressant). Step 3: Eliminate paroxetine as the trigger as the patient has been on it for a long time without issues. Step 4: Sumatriptan, a serotonin receptor agonist used for migraines, is the likely culprit. It can interact with SSRIs like paroxetine, leading to serotonin syndrome. Step 5: Summary: Acetaminophen (A) and ibuprofen (C) are unlikely to cause serotonin syndrome. Zolpidem (D) is less likely than sumatriptan to trigger serotonin syndrome in this case. Thus, the correct answer is B.
Question 3 of 5
What does 'pharmacokinetics' include?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
What is characteristic of the intramuscular route of drug administration?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Stimulation of liver microsomal enzymes can:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.