A 3-day-old neonate presented with numerous firm, yellow-white, 1-2 mm papules and pustules with a surrounding erythematous flare in several sites of the body surface but the palms and soles were spared. Intralesional contents demonstrated eosinophils in Wright-stained smears and culture was sterile. Of the following, the MOST likely diagnosis is

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Pediatric Integumentary System Questions

Question 1 of 5

A 3-day-old neonate presented with numerous firm, yellow-white, 1-2 mm papules and pustules with a surrounding erythematous flare in several sites of the body surface but the palms and soles were spared. Intralesional contents demonstrated eosinophils in Wright-stained smears and culture was sterile. Of the following, the MOST likely diagnosis is

Correct Answer: B

Rationale: Erythema toxicum is a common benign condition in neonates, presenting with pustules containing eosinophils and a sterile culture, sparing palms and soles, making B correct.

Question 2 of 5

Evaluate for PHACES in any patient with facial hemangioma involving significant area of face, one of the following is not a feature of PHACES

Correct Answer: D

Rationale: PHACES syndrome includes Posterior fossa, Hemangiomas, Arterial, Cardiac (e.g., coarctation), Eye, and Sternal defects. Ear abnormalities (D) are not part of the acronym.

Question 3 of 5

The Peutz-Jeghers syndrome is characterized by melanotic macules on the lips and mucous membranes and by gastrointestinal (GI) polyposis. Of the following, The MOST constant feature is

Correct Answer: B

Rationale: Buccal mucosal macules are the most constant and characteristic feature of Peutz-Jeghers syndrome, present in nearly all cases, making B correct.

Question 4 of 5

The MOST common agent implicated in the etiology of erythema multiforme (EM) is

Correct Answer: B

Rationale: Herpes simplex virus (HSV), particularly labialis, is the most common trigger for erythema multiforme, making B correct.

Question 5 of 5

Toxic epidermal necrolysis is characterized by the following EXCEPT

Correct Answer: C

Rationale: Toxic epidermal necrolysis (TEN) features widespread blisters and skin tenderness but not target lesions, which are typical of erythema multiforme, making C the exception.

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