ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A 28-year-old man who suffered a crush injury to his lumbar spine (L4 and L5) with disc herniation is managed with meperidine for pain control. He has been taking this medication for 6 months. In addition to pain relief, which of the following other effects is possible?
Correct Answer: C
Rationale: Long-term meperidine use can lead to neurotoxicity from normeperidine accumulation, causing seizures or tremors, distinct from typical opioid effects like constipation.
Question 2 of 5
A 47-year-old man with a history of spina bifida presents to the emergency department with a fever. His temperature was 102°F orally. He has a neurogenic bladder secondary to his spina bifida. A urinalysis showed an infection, and culture grew out vancomycin-resistant Enterococcus. He is started on Linezolid. What is the mechanism of resistance of bacteria to vancomycin?
Correct Answer: C
Rationale: Vancomycin-resistant Enterococcus (VRE) replaces D-alanine with D-lactate in its cell wall, reducing vancomycin binding affinity, a common resistance mechanism.
Question 3 of 5
A 24-year-old sexually active woman presents with vaginal itching and a greenish, frothy vaginal discharge. Her boyfriend is asymptomatic. She is prescribed with metronidazole for Trichomonas infection. Which of the following is involved in metronidazole’s action?
Correct Answer: B
Rationale: Metronidazole disrupts DNA in anaerobic organisms like Trichomonas vaginalis by forming reactive intermediates, leading to cell death.
Question 4 of 5
A 27-year-old man has been hospitalized with fatigue and feeling sick for the past 4 months. After many tests and labs, an HIV test is performed and comes back positive. His HIV viral load is 36,000 and CD4 count is 369. He is started on multidrug therapy for his HIV disease. One of the drugs is raltegravir. What is the mechanism of action of raltegravir?
Correct Answer: C
Rationale: Raltegravir, an integrase inhibitor, prevents HIV DNA integration into the host genome, a key step in viral replication.
Question 5 of 5
The following precautions about tetracycline use are true EXCEPT:
Correct Answer: D
Rationale: Tetracyclines are contraindicated in pregnancy and early childhood due to effects on teeth and bones, making D the incorrect precaution.