ATI RN
Pharmacology of CNS Drugs Questions
Question 1 of 5
A 27-year-old man is prescribed with an antidepressant for seasonal affective disorder. This particular antidepressant may also help him quit smoking. Which of the following antidepressants is he likely taking?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
The common mechanism of action of NSAIDs is inhibition of the following enzyme:
Correct Answer: B
Rationale: NSAIDs (e.g., ibuprofen, aspirin) inhibit cyclo-oxygenase (COX) enzymes (choice B), reducing prostaglandin synthesis, which mediates inflammation, pain, and fever. Cholinesterase (choice A) is targeted by anticholinesterases, not NSAIDs. Lipo-oxygenase (choice C) produces leukotrienes, unaffected by most NSAIDs. Phosphodiesterase (choice D) relates to cAMP, irrelevant here. COX inhibition is the unifying mechanism, critical for understanding NSAID effects and side effects like GI irritation.
Question 3 of 5
Morphine is useful in treatment of:
Correct Answer: A
Rationale: Morphine treats acute abdominal pain (choice A), like postoperative pain, via mu agonism, though diagnosis is key due to masking. Head injury (choice B) contraindicates it due to respiratory depression and ICP rise. Bronchial asthma (choice C) worsens with respiratory suppression. Neurogenic shock (choice D) isn't a primary indication. Acute pain aligns with morphine's analgesic role.
Question 4 of 5
A 47-year-old man presents with acute pain in his big toe. Lab tests reveal a serum uric acid level of 10 mg/dl. After treatment for the acute attack he was shifted to a drug that decreases both serum and urine level of uric acid. This drug is:
Correct Answer: A
Rationale: Allopurinol (choice A) reduces serum and urinary uric acid by inhibiting xanthine oxidase, preventing urate formation, ideal for chronic gout post-acute attack. Colchicine (choice B) and Indomethacin (choice C) treat acute inflammation, not uric acid levels. Probenecid (choice D) increases urinary uric acid excretion, not decreasing it. Allopurinol fits the description for long-term gout management.
Question 5 of 5
Anti-psychotic drugs produce the following side effects EXCEPT:
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.