A 25-year-old man presents to the emergency department with severe abdominal pain, rigors, and a temperature of 39°C. For the past 2 days, he has suffered from right lower quadrant pain and only came to the hospital when it suddenly worsened. The physician suspects ruptured appendicitis and administers imipenem with cilastatin. Cilastatin blocks which of the following enzymes to increase imipenem's efficacy?

A 25-year-old man presents to the emergency department with severe abdominal pain, rigors, and a temperature of 39°C. For the past 2 days, he has suffered from right lower quadrant pain and only came to the hospital when it suddenly worsened. The physician suspects ruptured appendicitis and administers imipenem with cilastatin. Cilastatin blocks which of the following enzymes to increase imipenem's efficacy?

A 55-year-old woman is hospitalized for treatment of osteomyelitis. The infectious organism is found to be susceptible to gentamicin so she is started on a once-daily dose of intravenous gentamicin. Which of the following symptoms may be a signal to the physician to stop gentamicin therapy?

A 16-year-old boy presents to the ambulatory care clinic with a persistent dry cough. He had cleaned out a barn attic that was full of bats about 2 weeks ago and has had the cough for 5 days. The physician suspects histoplasmosis. Which would be the best treatment for this patient?

The rationale behind the lack of use of the antibiotic tetracycline in modern day medicine relates to which of the following?

A 42-year-old man with a history of recurrent mycoplasma pulmonary infections presents with similar complaints. Sputum culture reveals that the organism present demonstrates resistance to erythromycin and the macrolide antibiotic class. What is the most likely explanation for this finding?