ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A 24-year-old man with Hodgkin’s lymphoma presents to the emergency department with chest pain for the past 2 days. An electrocardiogram shows nonspecific changes. An echocardiogram is performed that shows dilation of the left ventricle, and the diagnosis of dilated cardiomyopathy is made. He has been receiving chemotherapy for Hodgkin’s lymphoma over the last month. What medication is most likely responsible for his cardiomyopathy?
Correct Answer: D
Rationale: Doxorubicin, an anthracycline in Hodgkin’s regimens (e.g., ABVD), is notorious for causing dose-dependent dilated cardiomyopathy due to oxidative stress on cardiac myocytes.
Question 2 of 5
A 25-year-old man with multiple sexual partners begins to have flulike symptoms. He visits his doctor who recommends an HIV screening test based on his history. He is found to have an HIV infection and begins a drug regimen. Which of the following works by inhibiting fusion of the virion with T cells?
Correct Answer: D
Rationale: Maraviroc inhibits HIV fusion by blocking the CCR5 co-receptor on T cells, preventing viral entry, distinct from other HAART drugs targeting replication steps.
Question 3 of 5
A 26-year-old man with schizophrenia takes daily codeine for no apparent reason. He does not have issues with upper respiratory disease. Which of the following effects would be least likely to be exhibited by this patient?
Correct Answer: D
Rationale: Codeine, an opioid, causes analgesia, euphoria, sedation, and cough suppression (not dry cough), but tinnitus is not a typical effect, making it least likely.
Question 4 of 5
A 28-year-old man who suffered a crush injury to his lumbar spine (L4 and L5) with disc herniation is managed with meperidine for pain control. He has been taking this medication for 6 months. In addition to pain relief, which of the following other effects is possible?
Correct Answer: C
Rationale: Long-term meperidine use can lead to neurotoxicity from normeperidine accumulation, causing seizures or tremors, distinct from typical opioid effects like constipation.
Question 5 of 5
A 42-year-old woman who recently immigrated to the United States from Africa presents with diffuse abdominal pain and an unusual rash. The erythematous linear rash spreads from her right upper quadrant to the umbilicus. Laboratory testing confirms the diagnosis of Toxocara canis infection. What is the most appropriate treatment?
Correct Answer: C
Rationale: Mebendazole is effective against Toxocara canis (visceral larva migrans), inhibiting microtubule formation in the nematode, treating abdominal pain and rash.