A 23 year old female patient complains about periodical chill and body temperature rise up to 40oC, sense of heat taking turns with profuse sweating. The patient has had already 3 attacks that came once in two days and lasted 12 hours. She has lived in Africa for the last 2 months. Liver and spleen are enlarged. In blood: erythrocytes - 2,5x1012/l. What is the most probable diagnosis?

Correct Answer: A

Rationale: The most probable diagnosis is A: Malaria. The patient's symptoms of periodic chills, high fever, and profuse sweating, along with living in Africa where malaria is endemic, strongly suggest malaria. The enlarged liver and spleen are consistent with malaria infection. The low erythrocyte count indicates hemolysis, a common feature of malaria. Spotted fever and sepsis do not typically present with the same pattern of symptoms and travel history as seen in this case. Haemolytic anaemia would not explain the patient's fever episodes and other symptoms. Therefore, based on the symptoms, travel history, and laboratory findings, malaria is the most likely diagnosis.

Correct Answer: A

Rationale: The correct answer is A: Bordetella pertussis. Bordetella pertussis is the bacterium responsible for causing whooping cough, also known as pertussis. It produces toxins that damage the respiratory tract, leading to severe coughing fits. Haemophilus influenzae, Streptococcus pneumoniae, and Mycobacterium tuberculosis are not associated with whooping cough. Haemophilus influenzae can cause respiratory infections but not whooping cough. Streptococcus pneumoniae is known for causing pneumonia, and Mycobacterium tuberculosis causes tuberculosis, both different from whooping cough. Therefore, the correct answer is A as it is the specific bacterium linked to the disease in question.

Correct Answer: B

Rationale: The correct answer is B: Sexual transmission. The symptoms described are indicative of a vaginal yeast infection caused by Candida albicans. The presence of large gram-positive oval oblong cells forming pseudomycelium is characteristic of Candida infection. Sexual transmission is the most probable channel of infection as Candida can be transmitted through sexual contact. Endogenous infection (A) refers to infections originating from the body's own flora, which is not the case here. Contact infection (C) typically involves direct physical contact or fomite transmission, which is less likely in this scenario. Vector-borne transmission (D) involves transmission through vectors like mosquitoes or ticks, which is not relevant in this case.

Correct Answer: D

Rationale: The correct answer is D: Lamblia. The cysts described match the characteristics of Giardia lamblia, a protozoan parasite. Giardia cysts are oval-shaped, 50-60 microns in diameter, and contain 2 nuclei (macronucleus and micronucleus). Giardia is commonly found in contaminated water sources and can cause gastrointestinal illness in humans. Incorrect choices: A: Toxoplasma - Toxoplasma gondii is a parasite that causes toxoplasmosis, transmitted through ingestion of contaminated food or water, but its cysts do not match the description given in the question. B: Amoeba - Amoebas are single-celled organisms, but they do not typically form cysts with visible nuclei as described. C: Balantidium - Balantidium coli is a ciliated protozoan that can cause dysentery in humans, but its cysts do not

Correct Answer: C

Rationale: The correct answer is C because "Infectious disease" is a combination of both a clinical term (A) and a term expressing the possibility of developing certain symptoms in an infection (B). Infectious diseases are illnesses caused by pathogenic microorganisms, such as bacteria, viruses, parasites, or fungi, that can spread directly or indirectly from person to person. Therefore, the term encompasses both the clinical aspect of the disease and the potential symptoms that may manifest in an infected individual. Choices A and B alone do not fully capture the comprehensive definition of infectious disease, making C the correct answer. Choice D is incorrect as there is a correct answer in this case.

Correct Answer: C

Rationale: The correct answer is C: beaded. In an agar slant, beaded colonies appear as separate or semiconfluent, forming small, round colonies with gaps between them. This term accurately describes the appearance of the colonies in this context. A: Filiform colonies are dense and opaque with smooth edges, not separate or semiconfluent. B: Echinulate colonies have spiny projections, not the characteristic of separate or semiconfluent growth. D: Effuse colonies spread out extensively and lack defined borders, unlike the distinct appearance of separate or semiconfluent colonies.

Correct Answer: D

Rationale: The correct answer is D: protozoan. Babesiosis is caused by a protozoan parasite called Babesia. Protozoans are single-celled organisms that can cause various diseases in humans. Babesiosis is transmitted to humans through the bite of infected ticks. Bacteria (choice A), viruses (choice B), and helminths (choice C) are not responsible for causing babesiosis. Bacteria are typically responsible for diseases like Lyme disease, viruses for illnesses like Zika, and helminths for infections such as parasitic worms. Thus, the correct choice for the causative agent of babesiosis is a protozoan.

Correct Answer: C

Rationale: The correct answer is C because antibacterial chemotherapeutics need to be maximally toxic to microorganisms, not lead to allergic reactions, be stable, and have a wide spectrum of activity to effectively treat bacterial infections. A is incorrect because maximum toxicity to bacteria can lead to harmful side effects in the body. B is incorrect because rapid disintegration and insolubility in water would hinder the drug's effectiveness. D is incorrect because the basic requirements for antibacterial chemotherapeutics are outlined in option C.

Correct Answer: B

Rationale: The correct answer is B: Borrelia burgdorferi. Borrelia burgdorferi is the bacteria responsible for causing Lyme disease. It is transmitted to humans through the bite of infected black-legged ticks. Treponema pallidum causes syphilis, Leptospira interrogans causes leptospirosis, and Rickettsia rickettsii causes Rocky Mountain spotted fever. Borrelia burgdorferi is specifically associated with Lyme disease due to its transmission through tick bites and the characteristic symptoms it causes.