ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions
Question 1 of 5
A 21-year-old male has recently begun pimozide therapy for Tourette's disorder. His parents bring him to the emergency department. They describe that he has been having “different appearing tics†than before, such as prolonged contraction of the facial muscles. While being examined, he experiences opsichotomus (type of extrapyramidal spasm of the body in which the head and heels are bent backward and the body is bowed forward). Which of the following drugs would be beneficial in reducing these symptoms?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Pharmacologic actions of acetylsalicylic acid include all of the following EXCEPT:
Correct Answer: C
Rationale: Acetylsalicylic acid (aspirin) inhibits COX enzymes, reducing prostaglandin synthesis (choice D), yielding analgesic (choice A) and antipyretic (choice B) effects by decreasing pain mediators and hypothalamic heat regulation, respectively. However, it inhibits, not promotes, platelet aggregation (choice C) by blocking thromboxane A2 production, a pro-aggregatory prostaglandin, making it antiplatelet, used in cardiovascular prophylaxis. Promotion of aggregation would contradict its mechanism. This exception tests understanding of aspirin's unique antiplatelet action among NSAIDs, critical for its clinical applications.
Question 3 of 5
Trichloroethanol is the active metabolite of:
Correct Answer: D
Rationale: Chloral hydrate (choice D) is metabolized to trichloroethanol, which depresses the CNS, inducing sedation. Morphine (choice A) metabolizes to active compounds like morphine-6-glucuronide, not trichloroethanol. Clorazepate (choice B) becomes desmethyldiazepam, a benzodiazepine. Phenobarbitone (choice C) is a barbiturate, not metabolized to trichloroethanol. This identifies Chloral hydrate's metabolic pathway, key for its hypnotic use.
Question 4 of 5
The following receptors are affected by antipsychotic drugs EXCEPT:
Correct Answer: C
Rationale: Antipsychotics (e.g., haloperidol) block central D2 (choice A) and 5-HT2 receptors (choice B) for efficacy, and muscarinic receptors (choice D) peripherally, causing side effects. Peripheral H2 receptors (choice C), involved in gastric acid secretion, aren't significantly affected; H1 antagonism occurs instead. This exception clarifies antipsychotic receptor profiles.
Question 5 of 5
Buspirone is:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.