A 21-year-old female presented to clinic for lesions on her vulva. The painful and itchy lesions have a red base and are vesicular. She recently has had a new sexual partner. The diagnosis of herpes is established and the patient is started on acyclovir. She becomes resistant to acyclovir and it therefore becomes ineffective. What is the mechanism of resistance for acyclovir?

A 21-year-old female presented to clinic for lesions on her vulva. The painful and itchy lesions have a red base and are vesicular. She recently has had a new sexual partner. The diagnosis of herpes is established and the patient is started on acyclovir. She becomes resistant to acyclovir and it therefore becomes ineffective. What is the mechanism of resistance for acyclovir?

A 66-year-old man with a history of gout was recently diagnosed with non-Hodgkin’s lymphoma. Because of frequent gout attacks, he has been placed on allopurinol. He is started on medication for his lymphoma, and shortly after, he develops GI upset and elevated liver enzymes. Because of taking allopurinol, what medication should have been avoided in this patient?

A 47-year-old woman with a rheumatoid arthritis comes to clinic for her annual visit. Her arthritis has not worsened over the past 6 months since starting on infliximab. Her arthritis is worst in the joints of her hands. After her morning stiffness ceases, she can usually go through the rest of the day with minimal pain. What is the mechanism of action of infliximab?

A 37-year-old man with a schizophrenia presents to the emergency room with worsening symptoms. He has been hearing voices in his head that tell him to hurt other people. He is scared by these thoughts and wants help. He is currently taking risperidone. The physician changes him to clozapine. What should the physician monitor while the patient is taking clozapine?

A 46-year-old woman with chronic pelvic pain caused by endometriosis consults a pain management specialist regarding options for treatment. Which of the following statements is true regarding chronic pain management in this patient?