ATI RN
NCLEX questions on chemotherapy drugs Questions
Question 1 of 5
A 17-year-old high school football player presents to clinic with painful burning of his feet. Football practice started 3 weeks ago, and for the past week, he has had blisters and cracking of the skin of his feet. The skin between his toes is erythematous and scaly. He is diagnosed with tinea pedis and started on clotrimazole. What is the mechanism of action of clotrimazole?
Correct Answer: D
Rationale: Clotrimazole inhibits ergosterol synthesis by blocking 14-α-demethylase, weakening fungal membranes in tinea pedis (athlete’s foot).
Question 2 of 5
Which of the following is an advantage of benzyl penicillin use:
Correct Answer: A
Rationale: Benzyl penicillin’s water solubility allows IV use in emergencies, which is an advantage over its short duration, acid instability, and narrow spectrum.
Question 3 of 5
Alkalinization of urine is performed with sulphonamides to reduce crystalluria
Correct Answer: B
Rationale: Alkalinization increases sulphonamide solubility in urine, reducing crystalluria, making this statement correct.
Question 4 of 5
Antifungal drugs as amphotericin B has the following EXCEPT:
Correct Answer: B
Rationale: Amphotericin B binds ergosterol in fungal membranes, not cholesterol (a human cell component), though it can bind cholesterol with less affinity, reducing selectivity.
Question 5 of 5
The False statement concerning co-trimoxazole is:
Correct Answer: D
Rationale: Co-trimoxazole is not safe in pregnancy (teratogenic) or neonates (kernicterus risk), making D false.