ATI RN
Pharmacology/Lifespan Considerations Questions
Question 1 of 5
A 17-year-old girl is brought to the physician by her parents 30 minutes after having a generalized tonic-clonic seizure while playing in a soccer game. She currently takes no medications. Physical examination shows no abnormalities. After further testing including 24-hour continuous EEG monitoring, carbamazepine is prescribeThis patient's use of additional medications should be monitored because of which of the following changes in drug disposition after starting pharmacotherapy?
Correct Answer: D
Rationale: Carbamazepine induces hepatic cytochrome P450 enzymes (e.g., CYP3A4), increasing metabolism of itself (autoinduction) and other drugs, potentially reducing their efficacy. This requires monitoring co-administered medications (e.g., contraceptives, warfarin). Absorption (A), distribution (B), excretion (C), and recirculation (E) are not primarily affected by carbamazepine’s enzyme induction.
Question 2 of 5
Which route of drug administration is most likely to lead to the first-pass effect?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A small amount of the volume of distribution is common for lipophylic substances easy penetrating through barriers and widely distributing in plasma, interstitial and cell fluids:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
Half life (t 1/2) is the time required to:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
If an agonist can produce maximal effects and has high efficacy it’s called:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.