ATI RN
Principles of Pharmacology Questions
Question 1 of 5
A 17-year-old boy drank increasing amounts of alcohol when attending parties. He noticed that lately he was able to better tolerate alcohol effects and asked his physician the reason for this. The physician said that pharmacodynamic tolerance had probably occurred. Which of the following actions most likely mediated this tolerance?
Correct Answer: B
Rationale: Pharmacodynamic tolerance refers to the body's ability to adapt to the effects of a drug, leading to decreased responsiveness. In this case, the boy's ability to better tolerate alcohol effects indicates a form of tolerance mediated by homeostatic adaptive changes that counteract the drug effect. This type of tolerance involves physiological adjustments to mitigate the impact of the drug, allowing the individual to withstand higher doses. Therefore, the correct answer is B.
Question 2 of 5
What is the main site of distribution of infliximab, a drug used to treat rheumatoid arthritis?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A new drug was tested in an in vitro system. It was found that only one enantiomer of the racemic pair bound substantially to a specific receptor, whereas the other enantiomer showed negligible binding. Which of the following terms best defines this property?
Correct Answer: C
Rationale: The correct answer is C. Stereoselectivity refers to the phenomenon where one enantiomer of a drug has a significantly higher binding affinity to a receptor compared to its mirror-image enantiomer. In this scenario, one enantiomer binds substantially while the other shows negligible binding, indicating stereoselectivity in receptor binding. This property is crucial in drug development as it can impact the efficacy and safety profile of a medication. Intrinsic activity (choice A) refers to the ability of a drug to activate a receptor once bound, while affinity (choice B) is the strength of binding between a drug and its receptor. Potency (choice D) refers to the dose of a drug required to produce a specific effect, and variability (choice E) is the degree of inconsistency in response to a drug.
Question 4 of 5
Which of the following terms best defines the cimetidine-diazepam interaction in the 46-year-old woman?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Which of the following is most likely the main site of distribution of infliximab?
Correct Answer: A
Rationale: Infliximab, as a monoclonal antibody, is a large molecule that is more likely to distribute to tissues like fat due to their ability to store and release drugs slowly. Fat tissue is a common site of distribution for large molecules and lipophilic drugs. Therefore, fat tissue is the most likely main site of distribution for infliximab.