ATI RN
ATI Pharmacology Practice B 2023 Questions
Question 1 of 5
A 13-year-old female presents with 3 months of easy bruisability and bone pain. Complete blood count shows extreme leukocytosis. She is diagnosed with ALL and begins a chemotherapy regimen. One of her chemotherapeutic drugs is cyclophosphamide. What should also be given to avoid a potentially serious side effect of cyclophosphamide?
Correct Answer: A
Rationale: Cyclophosphamide in ALL risks hemorrhagic cystitis from acrolein, a toxic metabolite. Mesna binds acrolein, preventing bladder damage. Methylene blue , N-acetylcysteine , Ibuprofen , and Succimer (E) don't address this. Mesna's specificity ensures safe chemotherapy, critical in this young patient.
Question 2 of 5
Louie, who is to receive a blood transfusion asks the nurse what is the most common type of infection he could receive from the transfusion. The nurse teaches him that approximately 1 in 250,000 patients contract:
Correct Answer: C
Rationale: Hepatitis B infection is the most common serious infection that patients can contract from a blood transfusion. It is estimated that approximately 1 in 250,000 patients receiving a blood transfusion may contract Hepatitis B. Hepatitis B is a viral infection that affects the liver and can lead to serious complications if left untreated. Blood banks and healthcare facilities have strict screening and testing procedures in place to minimize the risk of transmitting Hepatitis B through blood transfusions. It is important for patients to be aware of this risk and to follow up with their healthcare provider if they experience any symptoms of Hepatitis B after a blood transfusion.
Question 3 of 5
Two days after admission, the nurse is reviewing laboratory results of the patient. Which is the most common electrolyte finding resulting from the administration of furosemide (Lasix)?
Correct Answer: C
Rationale: Furosemide (Lasix) is a loop diuretic commonly used to treat conditions such as edema and hypertension by increasing urine output. One of the most common electrolyte imbalances associated with the use of furosemide is hypokalemia, which is a low level of potassium in the blood. This occurs because furosemide increases the excretion of potassium in the urine by inhibiting its reabsorption in the kidneys. Hypokalemia can lead to various symptoms such as muscle weakness, cramps, and cardiac arrhythmias, making it important for healthcare providers to monitor potassium levels closely in patients receiving furosemide.
Question 4 of 5
When administering a loop diuretic to a patient, it is most important for the nurse to determine if the patient is also taking which drug?
Correct Answer: D
Rationale: Loop diuretics, such as furosemide, can interact with theophylline, a medication commonly used to treat asthma or chronic obstructive pulmonary disease (COPD). When both drugs are taken together, it can lead to an increased risk of theophylline toxicity due to decreased theophylline clearance. This can result in symptoms such as nausea, vomiting, seizures, and cardiac arrhythmias. Therefore, it is crucial for the nurse to determine if the patient is taking theophylline before administering a loop diuretic to prevent potential drug interactions and adverse effects.
Question 5 of 5
Which of the following describes the relationship of the blood concentration attained with initial dosing and the dose of drug given
Correct Answer: C
Rationale: The relationship of the blood concentration attained with initial dosing and the dose of drug given is best described by the concept of steady state. Steady state refers to the point at which the rate of drug input (dose) equals the rate of drug elimination, resulting in consistent drug levels in the blood. Achieving steady state typically requires several half-lives of the drug, during which the drug concentration gradually increases with each dose until it stabilizes. The dose of the drug given will influence how quickly steady state is reached and at what concentration the drug will be maintained in the body. Factors such as bioavailability, half-life, volume of distribution, and clearance play important roles in determining the dosage needed to reach and maintain steady state drug levels in the body.