A 10-day-old newborn presented with pallor, poor oral intake and abdominal distension, physical examination revealed stigmata of trisomy 21, hepatosplenomegaly, and his peripheral blood film showed low hemoglobin, high white cell count, low platelets and many blasts cells. Of the following, the MOST likely diagnosis at this stage is

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Pediatric Infectious Disease NCLEX Questions Questions

Question 1 of 5

A 10-day-old newborn presented with pallor, poor oral intake and abdominal distension, physical examination revealed stigmata of trisomy 21, hepatosplenomegaly, and his peripheral blood film showed low hemoglobin, high white cell count, low platelets and many blasts cells. Of the following, the MOST likely diagnosis at this stage is

Correct Answer: B

Rationale: Transient myeloproliferative syndrome is common in neonates with Down syndrome (trisomy 21) and resolves spontaneously in most cases.

Question 2 of 5

The MOST common histopathological subtype in childhood Hodgkin disease is

Correct Answer: B

Rationale: Nodular sclerosis is the most common subtype of Hodgkin lymphoma in children and adolescents.

Question 3 of 5

Of the following, the MOST common brain tumor is

Correct Answer: A

Rationale: Cerebellar astrocytoma is the most common pediatric brain tumor, often low-grade and resectable.

Question 4 of 5

A 6-month- old infant presented with multiple skin nodules and pallor, his CBC showed reduced blood elements with no abnormal cells. Abdominal sonogram showed small right adrenal mass with diffuse liver hypoechoic lesions. The bone marrow aspiration was highly suggestive of involvement by neuroblastoma. Of the following, the MOST likely stage is

Correct Answer: D

Rationale: Stage 4S involves infants <1 year with a primary tumor, skin/liver/bone marrow metastases, and favorable prognosis.

Question 5 of 5

The congenital anomalies that are associated with Wilms tumor are

Correct Answer: C

Rationale: Wilms' tumor is associated with aniridia, hemihypertrophy, and GU anomalies (e.g., in WAGR or Beckwith-Wiedemann syndromes).

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