ATI RN
ATI Pharmacology Practice A Questions
Question 1 of 5
Which of the following drugs need not be avoided or only used at a reduced dose in renal failure?
Correct Answer: A
Rationale: Renal failure alters drug clearance, requiring dose adjustments or avoidance. Prednisolone, a glucocorticoid, is metabolized hepatically to prednisone, with minimal renal excretion, making it safe without adjustment in renal failure. Netilmicin, an aminoglycoside, is renally cleared, risking ototoxicity if not reduced. Metformin, cleared renally, risks lactic acidosis in renal impairment, often avoided. Methotrexate, renally excreted, accumulates in failure, causing toxicity (e.g., marrow suppression). Tinzaparin, a low molecular weight heparin, requires adjustment due to renal clearance. Prednisolone's hepatic handling makes it the exception, safe for use in renal dysfunction without modification.
Question 2 of 5
The nurse is caring for a client receiving isoniazid (INH) for tuberculosis. Which instruction should the nurse include?
Correct Answer: C
Rationale: Isoniazid treats TB but risks hepatotoxicity, causing jaundice (yellowing skin, choice C), a serious sign needing immediate reporting to prevent liver failure. Food is optional'INH can be taken either way. Tyramine relates to MAOIs, not INH. Bedtime isn't specific'dosing is flexible. Reporting jaundice aligns with INH's side effect profile, critical in TB therapy where long-term use is common, making C the essential instruction for early detection and safety.
Question 3 of 5
Which patient would benefit from administration of simvastatin (Zocor) 80 mg?
Correct Answer: D
Rationale: A patient who has already been taking simvastatin (Zocor) for 12 months with no evidence of myopathy would benefit from administration of simvastatin 80 mg. This is because patients who have been on a stable dose of simvastatin without experiencing muscle-related side effects are considered to be tolerating the medication well. Increasing the dose to 80 mg may provide additional benefits in terms of lowering cholesterol levels without significant risk of myopathy.
Question 4 of 5
When administering heparin subcutaneously, the nurse will follow which procedure?
Correct Answer: D
Rationale: When administering heparin subcutaneously, the nurse should use a - to -inch, 25- to 30-gauge needle to inject the medication into the subcutaneous tissue. This needle size is appropriate for delivering the medication effectively and safely in the subcutaneous layer rather than deeper into the muscle. Using the correct needle size helps ensure proper absorption and reduces the risk of complications such as bleeding or bruising at the injection site.
Question 5 of 5
Which assessment finding, by the nurse, is a priority concern when a client receives pseudoephedrine (Sudafed)?
Correct Answer: C
Rationale: Pseudoephedrine's sympathomimetic action risks dysrhythmias, making an irregular heart rate a priority concern for immediate reporting. Fever , respiratory rate , and dry mouth are less urgent. C aligns with cardiovascular risks, making it the priority.