ATI RN
ATI Pharmacology Practice A Questions
Question 1 of 5
A 23-year-old man is a driver who is involved in a motor vehicle accident. He is found to have a blood alcohol level of 850 mg/dL. Because of the way the body handles ethanol, the conventional 'half-life' to describe its metabolism does not apply. Which of the following drugs at therapeutic concentrations exhibits the same property?
Correct Answer: B
Rationale: Ethanol's zero-order metabolism (constant rate) differs from first-order half-life kinetics. Phenytoin shares this-saturating hepatic enzymes at therapeutic levels, making it correct. Ibuprofen , Simvastatin , Tolbutamide , and Valproic acid (E) follow first-order kinetics. Phenytoin's saturation mimics ethanol's fixed clearance, relevant to toxicology.
Question 2 of 5
A patient is being discharged on anticoagulant therapy. The nurse will include in the patient- education conversation that it is important to avoid herbal products that contain which substance?
Correct Answer: B
Rationale: Ginkgo is the herbal product to avoid because it can interact with anticoagulant therapy and increase the risk of bleeding. Ginkgo has blood-thinning properties, which can further potentiate the anticoagulant effects of medications like warfarin, increasing the risk of bleeding complications. It's essential for patients on anticoagulant therapy to avoid herbal products containing ginkgo to prevent adverse effects and ensure the effectiveness of their prescribed medication.
Question 3 of 5
Mannitol (Osmitrol), an osmotic diuretic, is contraindicated to which conditions? Select all that apply.
Correct Answer: B
Rationale: Mannitol is contraindicated in patients with narrow-angle glaucoma. It can exacerbate the condition by causing an increase in intraocular pressure, leading to potential vision damage or loss. Therefore, caution should be exercised and alternative treatments considered for patients with narrow-angle glaucoma when considering the use of mannitol.
Question 4 of 5
Phenytoin is an antiarrhythmic and anticonvulsant that has an unlabeled use for:
Correct Answer: C
Rationale: Phenytoin is primarily known as an antiarrhythmic and anticonvulsant medication. However, it also has an unlabeled or off-label use for the management of neuropathic pain. Neuropathic pain is a condition that arises from damage or dysfunction affecting the nerves and can be challenging to treat. Phenytoin's mechanism of action in the central nervous system makes it potentially effective for neuropathic pain conditions, even though it is not its primary indication. It can help alleviate nerve-related pain, such as that associated with conditions like diabetic neuropathy or post-herpetic neuralgia. It is important to note that using medications for off-label purposes should be done under the guidance of a healthcare professional familiar with the drug's properties and potential side effects.
Question 5 of 5
What type of diuretic is furosemide?
Correct Answer: A
Rationale: Furosemide is a loop diuretic. Loop diuretics act on the thick ascending limb of the loop of Henle in the kidney to inhibit sodium and chloride reabsorption, leading to increased excretion of water and electrolytes such as potassium and calcium. Loop diuretics are potent and are often used to treat conditions like edema, heart failure, and hypertension. Furosemide is commonly utilized to manage conditions such as congestive heart failure, high blood pressure, and edema associated with certain medical conditions.