Correct Answer: B

Rationale: The correct answer is B: Migraines with aura. Estrogen in contraceptives can increase the risk of stroke in patients with migraines with aura due to its effect on blood clotting. Estrogen-progestin contraceptives should be avoided in these patients to reduce the risk of adverse cardiovascular events. Choices A, C, and D do not have a direct contraindication to estrogen-progestin contraceptives based on current guidelines.

Correct Answer: B

Rationale: The correct answer is B: A sebaceous cyst. A sebaceous cyst typically presents as a lump underneath the skin that can be squeezed to release a cheesy substance, consistent with Jacob's description. The formation of a prominent dimple when gently pinched is characteristic of a cyst, indicating it is filled with fluid or semi-solid material. Sebaceous cysts are usually benign and can grow slowly over time. Incorrect choices: A: An enlarged lymph node - Unlikely as lymph nodes are typically not associated with cheesy discharge or the formation of a dimple when pinched. C: An actinic keratosis - Unlikely as actinic keratosis is a precancerous skin condition caused by sun exposure, not presenting with cheesy discharge or a dimple. D: A malignant lesion - Unlikely as malignant lesions usually do not produce cheesy discharge and are more aggressive in growth compared to a sebaceous cyst.

Correct Answer: B

Rationale: The correct answer is B: Dopamine agonist. In early PD, dopamine agonists are preferred due to their lower risk of motor complications compared to levodopa. Dopamine agonists help improve motor symptoms by directly stimulating dopamine receptors. COMT inhibitors are usually used in combination with levodopa to prolong its effects. Levodopa is effective but can lead to motor complications with long-term use. Careful observation is not a treatment strategy and delays symptom management. Therefore, starting with a dopamine agonist is the most suitable option for early PD to manage symptoms effectively with minimal risk of motor complications.

Correct Answer: B

Rationale: The correct answer is B because decreased tactile fremitus suggests fluid or air in the pleural space, which can occur in conditions like pleural effusion or pneumothorax. This decrease in tactile fremitus is due to the transmission of vibrations from the vocal cords being impeded by the presence of fluid or air between the lung and chest wall. Choices A, C, and D are incorrect because decreased tactile fremitus is not typically associated with increased lung density, normal lung function, or lung tumors.

Correct Answer: B

Rationale: The correct answer is B: It was the first device to produce X-rays. The Crookes tube, invented by William Crookes, was crucial in the development of modern imaging technologies because it was the first device to produce X-rays. X-rays revolutionized medical diagnostics and imaging, leading to significant advancements in healthcare. Choices A, C, and D are incorrect because the primary significance of the Crookes tube was its role in producing X-rays, not demonstrating electromagnetic radiation principles, paving the way for the electron microscope, or advancements in nuclear medicine.