ATI RN
ATI N180 Pharmacology Exam Questions
Extract:
Question 1 of 5
Which of the following routes is affected by the first-pass effect?
Correct Answer: A
Rationale: The correct answer is A: Oral (PO). The first-pass effect refers to the metabolism of a drug in the liver before it reaches systemic circulation. When a drug is taken orally, it is absorbed in the gastrointestinal tract and then passes through the liver before entering the bloodstream. This can lead to significant drug metabolism and reduced bioavailability. Intravenous (IV), intramuscular (IM), and subcutaneous (S
C) routes bypass the liver initially, allowing the drug to enter systemic circulation directly, thus avoiding the first-pass effect.
Therefore, the correct route affected by the first-pass effect is the oral route.
Question 2 of 5
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Question 3 of 5
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Question 4 of 5
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Question 5 of 5
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