Correct Answer: A,D

Rationale: The correct answers are A and D. Conjugated equine estrogens (Premarin) are contraindicated in clients with a history of thromboembolic disease (choice
A) due to the increased risk of clot formation. Estrogens can promote clotting factors, exacerbating the condition. Additionally, in clients with atypical vaginal bleeding that is not diagnosed (choice
D), estrogen therapy can worsen or mask underlying causes of vaginal bleeding, such as endometrial or cervical cancer.

Choices B and C are incorrect because hypertension and depression are not absolute contraindications for conjugated equine estrogens.

Correct Answer: A

Rationale:
Rationale: A nurse should anticipate administering Propylthiouracil (PTU) to treat Graves' disease due to its mechanism of action as an antithyroid medication. PTU inhibits the synthesis of thyroid hormones, thus reducing the elevated T4 and T3 levels in Graves' disease. This helps to normalize the thyroid function and alleviate symptoms.

Summary of other choices:
B: Morphine sulfate is an opioid analgesic, not indicated for Graves' disease.
C: Sucralfate is a medication used to treat ulcers, not indicated for Graves' disease.
D: Metformin is an oral antidiabetic medication, not indicated for Graves' disease.
E, F, G: No information provided, but not indicated for Graves' disease.

Correct Answer: C

Rationale: The correct answer is C: an antagonistic effect. This is because when the antacid reduces the absorption of the tetracycline, it diminishes the effectiveness of the tetracycline. This is an example of drug-drug interaction where one drug interferes with the action of another. An antagonistic effect occurs when one drug diminishes the effect of another drug. In this case, the antacid is antagonizing the tetracycline, leading to decreased absorption and potentially reducing its therapeutic benefits.



Choices A, B, and D are incorrect. A is an allergic reaction, which is an immune system response to a drug and not related to drug interactions. B is a synergistic effect, which occurs when two drugs together produce a greater effect than the sum of their individual effects, not when one drug inhibits the action of another. D states "None of the above," which is also incorrect as the scenario described clearly matches with the definition of an antagonistic effect.

Correct Answer: A

Rationale: The correct answer is A: This medication inhibits COX-2 receptors only. Celecoxib is a selective COX-2 inhibitor, meaning it specifically targets and inhibits the enzyme cyclooxygenase-2. This selective inhibition reduces inflammation and pain without affecting COX-1, which is responsible for maintaining the stomach lining.

Choices B, C, and D are incorrect because celecoxib does not target mu or kappa receptors; these are opioid receptors involved in pain modulation, not the mechanism of action of celecoxib. Overall, understanding the pharmacological properties of celecoxib as a COX-2 inhibitor is crucial in providing safe and effective patient care.

Correct Answer: A

Rationale: The correct answer is A: Relief of muscle spasms related to muscle injury. Cyclobenzaprine is a muscle relaxant commonly used to treat muscle spasms and associated pain due to musculoskeletal conditions like muscle injuries. It works by blocking nerve impulses responsible for causing muscle spasms.
Choice B is incorrect as cyclobenzaprine is not used to treat malignant hyperthermia, which is a severe reaction to certain medications during anesthesia.
Choice C is incorrect as cyclobenzaprine does not treat osteoporosis, which is a bone disease.
Choice D is incorrect as cyclobenzaprine is not indicated for treating migraines, which are headaches.