ATI RN
ATI Nurs 180 Pharmacology Quiz II Questions
Extract:
Question 1 of 5
A client with a leukemia has been placed on methotrexate. Which of the following mechanism of actions below describes this medication?
Correct Answer: C
Rationale: The correct answer is C: Inhibits replication by blocking folic acid synthesis. Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, a key enzyme in the synthesis of folic acid, necessary for DNA replication. This action specifically targets rapidly dividing cells like cancer cells in leukemia.
Choice A is incorrect as methotrexate is not used to treat fungal infections.
Choice B is incorrect as methotrexate does not alter pH levels.
Choice D is incorrect as methotrexate does not target helper T cells but rather inhibits DNA synthesis in rapidly dividing cells.
Question 2 of 5
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Question 3 of 5
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Question 4 of 5
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Question 5 of 5
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