ATI RN
ATI nurs 180 Pharmacology Final Exam Questions
Extract:
Question 1 of 5
A nurse reads in a drug information guide that PO morphine has a high first-pass effect. Which of the following would the nurse expect?
Correct Answer: B
Rationale: The correct answer is B. When PO morphine has a high first-pass effect, it means that a significant portion of the drug is metabolized by the liver before reaching systemic circulation.
Therefore, administering the drug through a non-enteral route (such as intravenous) would bypass the liver metabolism, leading to higher bioavailability and increased effectiveness.
A: Incorrect. The drug will not be most effective when given orally due to the high first-pass effect.
C: Incorrect. The excretion rate is unrelated to the first-pass effect of the drug.
D: Incorrect. The liver, not the kidney, is responsible for the first-pass effect of morphine.
Question 2 of 5
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Question 3 of 5
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Question 4 of 5
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Question 5 of 5
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