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Herzing University NSG156 Questions

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What mechanism explains Diazepam’s observed clinical effects?

Correct Answer: A

Rationale: Diazepam, a benzodiazepine, enhances the effect of gamma-aminobutyric acid (GAB
A) at GABA-A receptors by increasing the frequency of chloride channel opening. This hyperpolarizes neuronal membranes, producing anxiolytic, sedative, and muscle relaxant effects. The rapid onset following IV administration aligns with its high lipid solubility. Diazepam does not block sodium channels or inhibit monoamine oxidase; its specific modulation of GABAergic neurotransmission underlies its effectiveness in anxiety, seizures, and muscle spasms.

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