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Herzing University NSG154 Questions

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Which mechanism best explains the therapeutic effect of folic acid in this patient?

Correct Answer: A

Rationale: Folic acid acts as an essential coenzyme in one-carbon transfer reactions necessary for nucleotide and DNA synthesis. In megaloblastic anemia, deficiency impairs cell division, leading to macrocytic red cells. Supplementation restores thymidylate and purine synthesis, promoting erythropoiesis and increasing reticulocyte count as the bone marrow response recovers. It does not enhance iron absorption or directly stimulate erythropoietin. The rise in reticulocytes after therapy confirms its role in nucleic acid metabolism and red blood cell maturation.

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