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Herzing University NSG150 Questions

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What mechanism explains Omeprazole’s effect on gastric acidity?

Correct Answer: A

Rationale: Omeprazole, a proton pump inhibitor (PPI), acts by irreversibly blocking the H⁺/K⁺-ATPase enzyme system located in the gastric parietal cell membrane, the final pathway for acid secretion. This results in profound and long-lasting suppression of gastric acid production. The measured rise in gastric pH from acidic to near-neutral (pH 6.5) reflects this inhibition. Unlike H₂ blockers such as ranitidine, PPIs provide prolonged acid control and promote ulcer healing, making them the first-line treatment for GERD and peptic ulcer disease.

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