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Herzing University NSG147 Questions

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What explains Hydralazine’s antihypertensive action?

Correct Answer: A

Rationale: Hydralazine reduces blood pressure by directly relaxing arteriolar smooth muscle, thereby decreasing systemic vascular resistance and promoting vasodilation. It acts through modulation of intracellular calcium metabolism in vascular smooth muscle rather than via the renin-angiotensin or diuretic pathways. The resulting drop in BP from 160/100 to 130/80 mmHg highlights its potent vasodilatory effect. This mechanism makes Hydralazine particularly useful for severe hypertension and hypertensive emergencies, though reflex tachycardia may occur as a compensatory response.

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