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Herzing University NSG138 Questions

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After administering Furosemide, urine output increased significantly. What is the drug’s mechanism of action?

Correct Answer: A

Rationale: Furosemide is a loop diuretic that inhibits the Na⁺-K⁺-2Cl⁻ co-transporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. The resulting diuresis reduces fluid overload and edema. The observed rise in urine output after IV administration confirms effective diuretic action. Furosemide does not promote water retention or aldosterone secretion and is distinct from angiotensin receptor blockers (ARBs). Its rapid onset and strong efficacy make it ideal for managing conditions such as heart failure and renal impairment-related edema.

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