Which of the following would be expected in a patient with Graves disease?

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Question 1 of 5

Which of the following would be expected in a patient with Graves disease?

Correct Answer: B

Rationale: Graves disease (hyperthyroidism) is caused by overstimulation of the thyroid gland by circulating antibodies to the thyroid-stimulating hormone (TSH) receptor (which then increases the production and secretion of triiodothyronine (T3) and thyroxine (T4), just as TSH would). Therefore, the signs and symptoms of Graves disease are the same as those of hyperthyroidism, reflecting the actions of increased circulating levels of thyroid hormones: increased heat production, weight loss, increased O2 consumption and cardiac output, exophthalmos (bulging eyes, not drooping eyelids), and hypertrophy of the thyroid gland (goiter). TSH levels will be decreased (not increased) as a result of the negative feedback effect of increased T3 levels on the anterior pituitary.

Question 2 of 5

The transport of lipid-soluble hormones in the blood is accomplished by

Correct Answer: D

Rationale: Lipid-soluble hormones (e.g., steroids) bind albumin and specific proteins (e.g., SHBG).

Question 3 of 5

A hormone's effective plasma concentration can be influenced by

Correct Answer: D

Rationale: All factors affect how much active hormone is available in plasma.

Question 4 of 5

Synergism occurs when

Correct Answer: B

Rationale: Synergism (e.g., glucagon and epinephrine) amplifies combined effects beyond individual actions.

Question 5 of 5

Which of the following hormones is released from the hypothalamus?

Correct Answer: A

Rationale: CRH (corticotropin-releasing hormone) is a hypothalamic hormone.

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