Which of the following hormones acts by an inositol 1,4,5-triphosphate (IP3)-Ca2+ mechanism of action?

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Question 1 of 5

Which of the following hormones acts by an inositol 1,4,5-triphosphate (IP3)-Ca2+ mechanism of action?

Correct Answer: D

Rationale: Gonadotropin-releasing hormone (GnRH) is a peptide hormone that acts on the cells of the anterior pituitary by an inositol 1,4,5-triphosphate (IP3)-Ca2+ mechanism to cause the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 1,25-Dihydroxycholecalciferol and progesterone are steroid hormone derivatives of cholesterol that act by inducing the synthesis of new proteins. Insulin acts on its target cells by a tyrosine kinase mechanism. Parathyroid hormone (PTH) acts on its target cells by an adenylate cyclase-cyclic adenosine monophosphate (cAMP) mechanism.

Question 2 of 5

Steroid hormones are

Correct Answer: D

Rationale: Steroids are cholesterol-derived, lipophilic, and act via intracellular receptors to induce protein synthesis.

Question 3 of 5

Select the correct statement about TSH.

Correct Answer: D

Rationale: TSH from the anterior pituitary stimulates thyroid hormone production.

Question 4 of 5

The posterior pituitary

Correct Answer: A

Rationale: The posterior pituitary releases ADH (vasopressin) stored from hypothalamic synthesis.

Question 5 of 5

The anterior pituitary

Correct Answer: C

Rationale: The anterior pituitary (adenohypophysis) secretes mostly tropic hormones (e.g., TSH).

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