Which is not associated with thrombotic thrombocytopenic purpura?

Correct Answer: A

Rationale: The correct answer is A: Thrombosis. Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and neurological deficits. Thrombosis is not a typical feature of TTP. In TTP, platelet aggregation leads to microthrombi formation, causing microangiopathic hemolytic anemia, thrombocytopenia, and neurological symptoms. Thrombosis, on the other hand, is more commonly associated with conditions such as deep vein thrombosis or pulmonary embolism. Therefore, choice A is not associated with TTP, making it the correct answer. Choices B, C, and D are incorrect as they are all features commonly seen in TTP.

Correct Answer: D

Rationale: Koilonychias, characterized by spoon-shaped nails, is specific to iron deficiency anemia due to impaired nail growth. In hemolytic anemia, sickle cell disease, and thalassemia major, nail abnormalities are not typically observed. Iron deficiency leads to brittle, spoon-shaped nails. Consequently, option D is the correct answer.

Correct Answer: B

Rationale: The correct answer is B: Leukemoid reaction. Döhle bodies are blue-gray cytoplasmic inclusions seen in neutrophils, indicating rough endoplasmic reticulum disruption. Leukemoid reaction is a benign condition with elevated white blood cell count due to infections, inflammation, or stress. In chronic myeloid leukemia (A), abnormal myeloid cells are present but not Döhle bodies. Chediak-Higashi syndrome (C) is a rare genetic disorder with giant granules in neutrophils, not Döhle bodies. Infectious mononucleosis (D) shows atypical lymphocytes but not Döhle bodies.

Correct Answer: C

Rationale: The correct answer is C: Partial Thromboplastin Time (PTT). Hemophilia is a bleeding disorder due to deficiency of clotting factors. PTT specifically measures the intrinsic pathway of coagulation, which is affected in hemophilia. Prothrombin time (A) measures the extrinsic pathway, not specific for hemophilia. Bleeding time (B) assesses platelet function, not relevant for hemophilia. Platelet count (D) evaluates the number of platelets, not the clotting factor deficiency seen in hemophilia.

Correct Answer: A

Rationale: Step 1: Type 1 hypersensitivity is an immediate allergic reaction. Step 2: IgE antibodies are responsible for triggering Type 1 hypersensitivity reactions. Step 3: IgG is not involved in Type 1 hypersensitivity. Step 4: Delayed reactions (Choice C) are not characteristic of Type 1 hypersensitivity. Therefore, the correct answer is A: IgE, as it is the key mediator of Type 1 hypersensitivity reactions. Choices B and C are incorrect because IgG is not involved and Type 1 hypersensitivity is not a delayed reaction. Choice D is incorrect because it includes choices B and C, which are not relevant to Type 1 hypersensitivity.