ATI LPN
Quiz Questions Hematologic System Questions
Question 1 of 5
Which chromosomal abnormalities are associated with multiple myeloma? (Choose one)
Correct Answer: A
Rationale: The correct answer is A (t(11;14)) as this translocation is specifically associated with multiple myeloma, involving the cyclin D1 gene on chromosome 11. This translocation leads to overexpression of cyclin D1, promoting cell cycle progression and contributing to the pathogenesis of multiple myeloma. Choice B (t(9;22)) is associated with chronic myeloid leukemia, not multiple myeloma. Choice C (t(15;17)) is related to acute promyelocytic leukemia. Choice D (t(8;14)) is seen in Burkitt lymphoma, not multiple myeloma. Thus, the correct answer is A due to its direct association with multiple myeloma.
Question 2 of 5
Chemically-induced tumors have tumor-associated transplantation antigens that
Correct Answer: B
Rationale: The correct answer is B because tumor-associated transplantation antigens can vary between different tumors of different histologic types even if induced by the same carcinogen. This is due to the fact that different histologic types of tumors can express different antigens, leading to variations in the transplantation antigens. Choice A is incorrect because tumor-associated transplantation antigens can differ even with the same carcinogen. Choice C is incorrect because the strength of the antigens is not specified in the question. Choice D is incorrect as tumor-associated transplantation antigens can indeed induce an immune response.
Question 3 of 5
Natural killer cells are
Correct Answer: D
Rationale: The correct answer is D because natural killer cells are a type of innate immune cell that can recognize and kill virus-infected cells without the need for prior sensitization. They are part of the body's first line of defense against viral infections. Choice A is incorrect because B cells are a type of adaptive immune cell involved in antibody production, not natural killer cells. Choice B is incorrect because cytotoxic T cells are also adaptive immune cells that require prior sensitization to target specific antigens. Choice C is incorrect because immunization typically boosts adaptive immune responses involving B and T cells, not natural killer cells.
Question 4 of 5
In the determination of serum insulin levels by radioimmunoassay, which one of the following is NOT needed?
Correct Answer: D
Rationale: The correct answer is D because in the determination of serum insulin levels by radioimmunoassay, we need isotope-labeled insulin (choice A) as a tracer for detection, anti-insulin antibody made in goats (choice B) to bind to insulin, and anti-goat gamma globulin made in rabbits (choice C) to detect the antibody bound to insulin. Isotope-labeled anti-insulin antibody made in goats (choice D) is not needed as it is not typically used in this assay. This choice would not contribute to the accurate measurement of serum insulin levels.
Question 5 of 5
An antigen found in relatively high concentration in the plasma of normal fetuses and a high proportion of patients with progressive carcinoma of the colon is
Correct Answer: B
Rationale: The correct answer is B: carcinoembryonic antigen (CEA). CEA is elevated in patients with progressive colon carcinoma and in normal fetuses. This is because CEA is produced during fetal development and is also present in certain cancers. It is not a viral antigen (A), as CEA is a protein produced by cells. Alpha-fetoprotein (C) is elevated in certain liver conditions and cancers, but not specifically in colon carcinoma. Heterophil (D) is a type of antibody produced in response to infection, not related to CEA levels in colon carcinoma.