What is the major metabolically available storage form of iron in the body?

Correct Answer: B

Rationale: The correct answer is B: Ferritin. Ferritin is the major metabolically available storage form of iron in the body. It stores excess iron in a soluble and non-toxic form, releasing it when needed for various physiological functions. Rationale: 1. Ferritin is a protein that binds and stores iron within its structure. 2. It helps regulate the levels of iron in the body by storing excess iron and releasing it when needed. 3. Hemosiderin is an insoluble form of iron storage, not readily available for metabolism. 4. Transferrin is a transport protein that carries iron in the blood, not a storage form. 5. Hemoglobin is a protein in red blood cells that carries oxygen, not a storage form of iron. Summary: Ferritin is the correct answer as it is the primary metabolically available storage form of iron, while the other choices are incorrect as they do not serve as major storage forms of iron in the body.

Correct Answer: D

Rationale: The correct answer is D: Pulmonary embolism. A pulmonary embolism occurs when a blood clot from another part of the body, typically the legs (DVT), travels to the lungs and blocks a pulmonary artery. This can be fatal if not promptly treated. Thromboembolism (A) is a general term for blood clots that travel in the bloodstream. DVT (B) specifically refers to a blood clot in a deep vein, often in the legs. PAD (C) stands for peripheral artery disease, which is caused by atherosclerosis and results in reduced blood flow to the extremities, but it does not typically lead to fatal clot formation in the circulation like a pulmonary embolism does.

Correct Answer: A

Rationale: The correct answer is A: TRUE. PCR amplifies DNA, making it sensitive enough to detect low numbers of neoplastic cells, even in patients with reduced cell counts due to treatment. This can help in early detection of relapse. Choice B is incorrect because PCR can indeed improve sensitivity in such cases. Choice C is incorrect as PCR consistently enhances sensitivity. Choice D is incorrect as PCR can be used in both remission and relapse scenarios.

Correct Answer: A

Rationale: Step 1: Intravascular hemolysis occurs within blood vessels due to mechanical trauma. Step 2: Trauma to red blood cells (RBCs) while in circulation can lead to their destruction. Step 3: This destruction releases hemoglobin into the bloodstream. Step 4: The released hemoglobin can cause complications like kidney damage. Step 5: Therefore, intravascular hemolysis is the result of trauma to RBCs in circulation. Summary: Choice A is correct because trauma to RBCs in circulation can indeed lead to intravascular hemolysis. Choices B, C, and D are incorrect because they do not accurately reflect the process of intravascular hemolysis.

Correct Answer: A

Rationale: The correct answer is A (2). RPI (Reticulocyte Production Index) is calculated as: Observed Reticulocyte Count (%) x (Patient's Hct/Normal Hct). Given values: Observed reticulocyte count=6%, Hct=30%. Therefore, RPI = 6% x (30%/45%) = 6% x 0.67 = 4.02 ≈ 4. Since RPI is rounded to the nearest whole number, the correct RPI would be 4. Therefore, the correct answer is A (2). Other choices (B, C, D) are incorrect as they do not result from the correct calculation of RPI.