The usual treatment for iron-deficiency anemia includes:

Correct Answer: B

Rationale: Step-by-step rationale for why Choice B is correct: 1. Iron-deficiency anemia is due to low iron levels in the body. 2. Ferrous sulfate is a common iron supplement used to increase iron levels. 3. Non-enteric-coated form is preferred for better absorption. 4. Enteric-coated or sustained-release forms hinder absorption. Summary: A: Vitamin B12 is not used for iron-deficiency anemia. C: Enteric-coated or sustained-release forms hinder absorption. D: Whole blood transfusion is not the first-line treatment for iron-deficiency anemia.

Correct Answer: C

Rationale: The correct answer is C: Pancytopenia. Pancytopenia refers to a reduction in all three major blood cell types (red blood cells, white blood cells, and platelets). In the given scenario where the entire CBC is suppressed due to anemia, infection, or hemorrhage, it signifies a decrease in all blood cell types. A: Erythroplasia specifically refers to abnormal growth of red blood cells, not a suppression of all blood cell types. B: Thrombocytopenia is the reduction in platelet count, not all blood cell types. D: Leukopenia is the decrease in only white blood cells, not all blood cell types. Therefore, C is the correct answer in this context.

Correct Answer: A

Rationale: The correct answer is A because both vitamin B12 and iron can have reduced absorption when taken with drugs that decrease stomach acid like PPIs and H2 blockers. This is due to the acidic environment in the stomach being necessary for the absorption of these nutrients. Therefore, taking them with these medications can lead to deficiencies. Methyldopa, metformin, and antibiotics do not directly interact with vitamin B12 or iron absorption, making them incorrect choices.

Correct Answer: A

Rationale: The correct answer is A: Coombs test. The Coombs test detects antibodies attached to red blood cells, a characteristic of hemolytic anemia. This test helps identify the presence of autoimmune hemolytic anemia. B: Genetic testing is not typically used to detect hemolytic anemia as it focuses on genetic mutations rather than the antibodies causing the condition. C: Peripheral blood smear can show abnormal red blood cell shapes in hemolytic anemia but does not directly detect the presence of antibodies causing the hemolysis. D: Schilling test is used to assess vitamin B12 absorption and is not relevant to detecting hemolytic anemia.

Correct Answer: A

Rationale: The correct answer is A: TRUE. Isozymes of 2C, specifically CYP2C9, play a crucial role in metabolizing warfarin. Variants of CYP2C9 can lead to variations in warfarin metabolism, affecting its efficacy and risk of bleeding. Therefore, isozymes of 2C can significantly impact warfarin therapy. Choice B (FALSE) is incorrect because multiple studies have shown the impact of CYP2C9 isozymes on warfarin metabolism. Choice C (Sometimes) is vague and does not acknowledge the consistent influence of CYP2C9 on warfarin. Choice D (Only in high doses) is incorrect as CYP2C9 variants affect warfarin metabolism irrespective of the dose administered.