Reviewing CBC for a patient before knee arthroscopy. Which value is most important to report to the physician?

Correct Answer: D

Rationale: The correct answer is D: White blood cell count of 16,000/mm³. Elevated WBC count could indicate an infection, which is crucial to report before knee arthroscopy to prevent complications. Hematocrit (A) and hemoglobin level (B) are important but not as urgent for this procedure. Platelet count (C) is not directly related to infection detection.

Correct Answer: B

Rationale: The most concerning symptom for a patient on cyclosporine post-transplant is nontender groin swelling (Choice B) due to the risk of developing nephrotoxicity from cyclosporine. Groin swelling may indicate lymphoproliferative disorder or nephrotic syndrome, both associated with cyclosporine use. Bleeding gums (Choice A) may be due to gum disease but are not directly related to cyclosporine. Occasional nausea (Choice C) is a common side effect of cyclosporine but is usually mild and not as concerning. Numbness and tingling of feet (Choice D) may indicate peripheral neuropathy, which can be a side effect of cyclosporine but is less concerning than the potential kidney damage indicated by groin swelling.

Correct Answer: B

Rationale: Rationale: Von Willebrand factor plays a crucial role in primary hemostasis by binding platelets to the subendothelium at sites of vascular injury, facilitating platelet adhesion and aggregation. This is important for forming a platelet plug to stop bleeding. Choices A and C are incorrect because von Willebrand factor does not directly bind platelets to each other or to a phospholipid surface. Choice D is incorrect because von Willebrand factor does not carry factor VII, but it does carry factor VIII.

Correct Answer: C

Rationale: The correct answer is C: Reed-Sternberg cell. These large, abnormal cells are characteristic of Hodgkin lymphoma. They originate from B cells but have lost most B cell markers. They express CD30 and CD15. A is incorrect as Hodgkin lymphoma is not derived from cytotoxic T cells. B is incorrect as it is not a malignancy involving NK cells. D is incorrect as Hodgkin lymphoma does not involve CD33+ clonal B cells.

Correct Answer: C

Rationale: The correct answer is C, Factor VIII. Vitamin K deficiency primarily affects the synthesis of Factors II, VII, IX, and X. Factor VIII is not dependent on vitamin K for its synthesis since it is a co-factor for Factor IX. Therefore, Factor VIII levels remain unaffected in Vitamin K deficiency. Factors II, VII, and IX are all vitamin K-dependent factors, making them incorrect choices.