ATI LPN
NCLEX PN Pharmacology Practice Questions Questions
Question 1 of 9
Nutritional deficiencies that may impact drug action include:
Correct Answer: A
Rationale: Choice A is correct because vitamin K deficiency reduces clotting factor synthesis, enhancing warfarin's anticoagulant effect, a direct drug action impact. Choice B is incorrect as vitamin C deficiency (scurvy) doesn't significantly alter drug action pharmacokinetically. Choice C is wrong because B12 deficiency affects neurology, not drug metabolism broadly. Choice D is incorrect since only vitamin K has a specific, notable drug interaction.
Question 2 of 9
The major reason for not crushing a sustained-release capsule is that, if crushed, the coated beads of the drugs could possibly result in:
Correct Answer: B
Rationale: Choice B is correct because crushing a sustained-release capsule releases all drug at once, bypassing controlled release, which can lead to toxic levels quickly. Choice A is incorrect as disintegration isn't harmful itself, just alters release. Choice C is wrong because malabsorption isn't the primary risk—overdose is. Choice D is incorrect since deterioration implies drug degradation, not the immediate danger of crushing.
Question 3 of 9
The Vaccine Adverse Events Reporting System is:
Correct Answer: B
Rationale: Choice B is correct because VAERS is a voluntary system for providers and consumers to report vaccine ADRs, aiding safety monitoring without mandate. Choice A is incorrect as reporting isn't mandatory. Choice C is wrong because VAERS collects data, not sends alerts. Choice D is incorrect since it's not activated by proven effects—it's ongoing surveillance.
Question 4 of 9
Drugs that are more likely to cause medication errors include:
Correct Answer: A
Rationale: Choice A is correct because lisinopril and enalapril, both ACE inhibitors, have similar names and uses, increasing error risk due to confusion. Choice B is incorrect as amoxicillin and penicillin are distinct enough in naming and form. Choice C is wrong because atenolol and propranolol, while beta blockers, differ more in name recognition. Choice D is incorrect since A is the strongest example.
Question 5 of 9
A patient's nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:
Correct Answer: A
Rationale: Choice A is correct because hypoalbuminemia lowers albumin levels, which bind drugs in plasma; this alters distribution to tissues, potentially increasing free drug concentrations and affecting efficacy or toxicity. Choice B is incorrect as solubility relates to absorption, not albumin binding. Choice C is wrong because less albumin means more free drug, not less, due to reduced binding. Choice D is incorrect since albumin-bound drugs are less readily excreted; lower binding prolongs drug presence in circulation.
Question 6 of 9
Management of withdrawal symptoms includes:
Correct Answer: D
Rationale: Choice D is correct because tapering (reduces shock), supportive care (e.g., hydration), and medications (e.g., methadone for opioids) all manage withdrawal, per treatment protocols. Choice A is incorrect alone as it's one method. Choice B is wrong by itself because care is just part. Choice C is incorrect solo since meds are only one option.
Question 7 of 9
Drugs that may cause gynecomastia in men include:
Correct Answer: A
Rationale: Choice A is correct because spironolactone blocks androgen receptors, causing gynecomastia, a well-documented side effect. Choice B is incorrect as atenolol (beta blocker) rarely causes it. Choice C is wrong because lisinopril (ACE inhibitor) doesn't typically lead to gynecomastia. Choice D is incorrect since only spironolactone is a clear culprit.
Question 8 of 9
The Orange Book is used to:
Correct Answer: A
Rationale: Choice A is correct because the FDA's Orange Book lists generic drugs' therapeutic equivalence (e.g., AB rating) to brand-name drugs, aiding substitution decisions. Choice B is incorrect as it's not a brand-name catalog. Choice C is wrong because it doesn't provide pricing. Choice D is incorrect since only A fits.
Question 9 of 9
Nutritional deficiencies that may impact drug action include:
Correct Answer: A
Rationale: Choice A is correct because vitamin K deficiency reduces clotting factor synthesis, enhancing warfarin's anticoagulant effect, a direct drug action impact. Choice B is incorrect as vitamin C deficiency (scurvy) doesn't significantly alter drug action pharmacokinetically. Choice C is wrong because B12 deficiency affects neurology, not drug metabolism broadly. Choice D is incorrect since only vitamin K has a specific, notable drug interaction.