Mutations of the ATP7B gene is characteristic of which of the following?

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Question 1 of 5

Mutations of the ATP7B gene is characteristic of which of the following?

Correct Answer: D

Rationale: ATP7B gene mutations cause Wilson disease, leading to copper accumulation; the document error (e) is corrected to (d).

Question 2 of 5

During the 'window phase' of acute HIV infection, individuals:

Correct Answer: D

Rationale: During the window phase, individuals are highly infectious despite often being asymptomatic.

Question 3 of 5

A 49-year-old African-American man presents with an unremarkable history. Six months ago, his serum creatinine was 0.9 mg/dl. He presents with 2+ pitting edema to the knees. A renal biopsy revealed FSGS not otherwise specified. When compared with an identical Caucasian patient, which ONE of the following statements is MORE likely to be true in African Americans?

Correct Answer: B

Rationale: FSGS progresses more rapidly to ESKD in African Americans due to genetic predisposition, particularly APOL-1 variants.

Question 4 of 5

Which of the following is not an extra-articular manifestation of Rheumatoid Arthritis?

Correct Answer: C

Rationale: Tophi are characteristic of gout, not rheumatoid arthritis (RA). Sjogren's, Felty's, and subcutaneous nodules are well-recognized extra-articular RA manifestations, per rheumatology guidelines.

Question 5 of 5

A patient with heart failure who reports intermittent shortness of breath during the night is experiencing

Correct Answer: D

Rationale: Dyspnea that occurs at night is known as paroxysmal nocturnal dyspnea. Orthopnea is known as dyspnea when lying down. Intermittent shortness of breath at night is not known as paroxysmal atrial tachycardia. Sleep apnea is an absence of breathing during sleep.

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