Most frequent humoral immunologic abnormality in patients with ataxia-telangiectasia is:

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Question 1 of 5

Most frequent humoral immunologic abnormality in patients with ataxia-telangiectasia is:

Correct Answer: B

Rationale: Selective IgA deficiency is most common in ataxia-telangiectasia, impairing mucosal immunity (NORD). Other options (A, C-E) are less typical.

Question 2 of 5

Best drug of choice for a severe listeria infection is:

Correct Answer: C

Rationale: Ampicillin plus gentamicin is the standard for severe Listeria infections, enhancing efficacy (IDSA). A-D are suboptimal.

Question 3 of 5

An infant appears with periorbital fullness, full cheeks, long philtrum, anteverted nares, broad nasal bridge, and an open mouth. Physical examination reveals an absence of heart murmur. Laboratory findings reveal normal CBC, normal electrolytes, and high serum ionized calcium. Most likely diagnosis is:

Correct Answer: C

Rationale: Williams syndrome matches the facial features and transient hypercalcemia, with no murmur if cardiac defects are absent (NIH). A-D don’t fit.

Question 4 of 5

A 6-month-old girl appears with a history of wheezing following an upper respiratory infection (URI). She improves significantly after nebulized albuterol therapy. Most likely diagnosis is:

Correct Answer: D

Rationale: Bronchiolitis is common at 6 months post-URI, with wheezing responsive to albuterol (AAP). Asthma is less likely under 1 year, and A, B, E don’t fit the response pattern.

Question 5 of 5

A child with a history of cystic fibrosis suddenly develops massive hemoptysis. The next step in management is:

Correct Answer: B

Rationale: Bronchial artery embolization is the urgent treatment for massive hemoptysis in cystic fibrosis, per CFF. A, C-E don’t address bleeding.

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