In Chronic Lymphocytic Leukemia the Lymphocyte appearance: small or slightly larger than normal, hypercondensed (almost appearing), nuclear chromatin pattern, bare nuclei called 'smudge cells' are common.

Correct Answer: A

Rationale: The correct answer is A: Soccer-ball. In Chronic Lymphocytic Leukemia (CLL), lymphocytes typically appear small or slightly larger than normal, with hypercondensed nuclear chromatin and the presence of bare nuclei called 'smudge cells'. The comparison to a soccer-ball is apt as soccer-balls are relatively small, round, and have a unique pattern on their surface. Choices B, C, and D are incorrect as they do not accurately describe the characteristic appearance of lymphocytes in CLL. B: Basketball is too large and lacks the hypercondensed nuclear chromatin pattern. C: Football is not round and lacks the specific nuclear chromatin pattern. D: Tennis-ball is also too small and does not exhibit the characteristic appearance of CLL lymphocytes.

Correct Answer: C

Rationale: The correct answer is C: Peripheral protein. Peripheral proteins are located on the surface of the erythrocyte membrane and play a crucial role in maintaining cell shape, structure, and deformability. They interact with the cytoskeleton to support the membrane's integrity. Integral proteins (choice A) are embedded within the lipid bilayer but do not directly impact cell shape. Exterior lipids (choice B) are components of the membrane but do not have a primary role in determining cell structure. Interior lipids (choice D) are important for membrane fluidity but do not contribute significantly to cell shape and deformability.

Correct Answer: C

Rationale: The correct answer is C: Pyruvate Kinase. This enzyme deficiency in the Embden-Meyerhof pathway leads to the accumulation of intermediates, causing red blood cell damage and hemolytic anemia. Pyruvate Kinase catalyzes the conversion of phosphoenolpyruvate to pyruvate, a crucial step in glycolysis. In contrast, choices A, B, and D are not directly related to the final step of glycolysis and do not lead to the accumulation of intermediates causing hemolytic anemia. Hexokinase is involved in the initial step of glycolysis, Phosphofructokinase in the committed step, and Glyceraldehyde 3-Phosphate Dehydrogenase in the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate.

Correct Answer: B

Rationale: The correct answer is B: Auer rods. A bone marrow biopsy in a patient with leukemia may show Auer rods, which are needle-shaped cytoplasmic inclusions found in myeloid cells. Auer rods are characteristic of acute myeloid leukemia. Smudge cells (choice A) are seen in chronic lymphocytic leukemia. Reed-Sternberg cells (choice C) are found in Hodgkin's lymphoma. Lytic lesions (choice D) are seen in multiple myeloma, but are not typically identified on a bone marrow biopsy. Thus, Auer rods are the most likely finding on a bone marrow biopsy in a patient with leukemia.

Correct Answer: C

Rationale: The correct answer is C: patchy, irregular fluorescence of the glomerular basement membrane. In acute glomerulonephritis, there is immune complex deposition in the glomeruli leading to inflammation. The immune complexes contain IgG antibodies, which will bind to the glomerular basement membrane. When stained with fluorescein-conjugated anti-human IgG antibody, the presence of IgG antibodies in the glomerular basement membrane will result in patchy, irregular fluorescence patterns. Choice A is incorrect as there should be fluorescence due to IgG deposition. Choice B is incorrect as the fluorescence pattern is not uniform. Choice D is incorrect as B cells are not typically involved in the pathology of acute glomerulonephritis.