Absolute lymphocytosis with either hepatomegaly or splenomegaly with or without lymphadenopathy is what stage in CLL prognosis Scoring-Rai Staging System?

Correct Answer: C

Rationale: Rationale: Absolute lymphocytosis with hepatomegaly or splenomegaly indicates an intermediate risk in Rai Staging System, which corresponds to Stage II. Hepatomegaly or splenomegaly alone would be Stage I, while lymphadenopathy alone would be Stage 0. Stage III in CLL prognosis involves anemia and/or thrombocytopenia along with lymphocytosis. Therefore, the correct answer is Stage II. Other choices are incorrect because they do not accurately reflect the specific combination of symptoms described in the question.

Correct Answer: B

Rationale: The correct answer is B: Lymphocyte. Lymphocytes can develop in sites other than the bone marrow, such as the thymus and lymph nodes. Monocytes, Megakaryocytes, and Neutrophils develop exclusively in the bone marrow. Monocytes differentiate into macrophages and dendritic cells, while Megakaryocytes produce platelets. Neutrophils are a type of white blood cell involved in the immune response. Therefore, only lymphocytes have the ability to develop outside the bone marrow, making choice B the correct answer.

Correct Answer: B

Rationale: The correct answer is B: Proper handwashing. This is the most important practice in preventing the spread of disease because it effectively removes germs and bacteria from hands, reducing the risk of transmission. Handwashing is crucial in healthcare settings to prevent infections. A: Wearing masks during patient contact is important, but handwashing is more effective in preventing disease spread as it directly addresses the transmission of germs through hands. C: Wearing disposable lab coats is important for infection control but not as crucial as proper handwashing, which directly removes germs from hands. D: Identifying specimens with red labels is important for handling potentially infectious materials, but handwashing is still the most essential practice in preventing disease spread as it addresses the primary mode of transmission through hands.

Correct Answer: A

Rationale: The correct answer is A (t(11;14)) as this translocation is specifically associated with multiple myeloma, involving the cyclin D1 gene on chromosome 11. This translocation leads to overexpression of cyclin D1, promoting cell cycle progression and contributing to the pathogenesis of multiple myeloma. Choice B (t(9;22)) is associated with chronic myeloid leukemia, not multiple myeloma. Choice C (t(15;17)) is related to acute promyelocytic leukemia. Choice D (t(8;14)) is seen in Burkitt lymphoma, not multiple myeloma. Thus, the correct answer is A due to its direct association with multiple myeloma.

Correct Answer: A

Rationale: The correct answer is A: IgE antibody. IgE antibodies are involved in Type I hypersensitivity reactions, such as anaphylaxis caused by bee stings. IgE antibodies bind to mast cells and basophils, triggering the release of inflammatory mediators like histamine, causing respiratory distress and unconsciousness. IgG antibodies (choice B) are not typically involved in immediate hypersensitivity reactions. Sensitized T cells (choice C) are involved in delayed hypersensitivity reactions, not immediate ones like anaphylaxis. Complement (choice D) is part of the innate immune system and is not directly involved in IgE-mediated allergic reactions like anaphylaxis.